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- W1485118047 abstract "The transcription factor nuclear factor-kB (NF-kB) is critical for the induction of inflammatory responses in T-cells, survival and differentiation. Antigen receptor (TCR) and co-receptor CD28 are the central regulators of NF-kB activation in T-cells. Progress in understanding NF-kB activation in T-cells has occurred over the years with the identification of individual adapters such as ADAP and GRB-2 and enzymes such as PKC-θ that regulate NF-kB. However, little is known whether the engagement of distinct modules by the TCR and CD28 account for the cooperative effects of the two receptors in activating NF-kB. In this review, we discuss recent advances in our understanding of NF-kB regulation by TCR and CD28." @default.
- W1485118047 created "2016-06-24" @default.
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- W1485118047 date "2015-05-02" @default.
- W1485118047 modified "2023-09-26" @default.
- W1485118047 title "Distinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cells" @default.
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- W1485118047 doi "https://doi.org/10.14800/ics.613" @default.
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