Matches in SemOpenAlex for { <https://semopenalex.org/work/W1485179699> ?p ?o ?g. }
- W1485179699 endingPage "5688" @default.
- W1485179699 startingPage "5683" @default.
- W1485179699 abstract "The mechanism of action of microbial adjuvants in promoting the differentiation of autoimmune effector cells remains to be elucidated. We demonstrate that CpG-containing oligodeoxynucleotides (ODN) can completely substitute for heat-killed mycobacteria in the priming of encephalitogenic myelin-reactive T cells in vivo. The adjuvanticity of the CpG ODN was secondary to their direct ability to induce IL-12 or to act synergistically with endogenous IL-12 to promote Th1 differentiation and encephalitogenicity. T cells primed in the absence of CpG with Ag and IFA alone appeared to be in a transitional state and had not undergone differentiation along a conventional Th pathway. Unlike Th2 cells, they expressed low levels of the IL-12R beta 2 subunit and retained the ability to differentiate into encephalitogenic effectors when reactivated in vitro under Th1-polarizing conditions. These results support the use of CpG ODN as adjuvants but also suggest that they could potentially trigger autoimmune disease in a susceptible individual." @default.
- W1485179699 created "2016-06-24" @default.
- W1485179699 creator A5005119540 @default.
- W1485179699 creator A5012998783 @default.
- W1485179699 creator A5039903543 @default.
- W1485179699 date "2000-06-01" @default.
- W1485179699 modified "2023-09-28" @default.
- W1485179699 title "CpG Oligonucleotides Are Potent Adjuvants for the Activation of Autoreactive Encephalitogenic T Cells In Vivo" @default.
- W1485179699 cites W1518943038 @default.
- W1485179699 cites W1524792851 @default.
- W1485179699 cites W1526621387 @default.
- W1485179699 cites W1527057464 @default.
- W1485179699 cites W1894178301 @default.
- W1485179699 cites W1932743066 @default.
- W1485179699 cites W1947288464 @default.
- W1485179699 cites W1972964423 @default.
- W1485179699 cites W1990374418 @default.
- W1485179699 cites W1990639778 @default.
- W1485179699 cites W1995545582 @default.
- W1485179699 cites W1995991884 @default.
- W1485179699 cites W2002265763 @default.
- W1485179699 cites W2009660986 @default.
- W1485179699 cites W2013642092 @default.
- W1485179699 cites W2025345914 @default.
- W1485179699 cites W2025690599 @default.
- W1485179699 cites W2027729283 @default.
- W1485179699 cites W2030689421 @default.
- W1485179699 cites W2033441782 @default.
- W1485179699 cites W2034160116 @default.
- W1485179699 cites W2034169866 @default.
- W1485179699 cites W2037233457 @default.
- W1485179699 cites W2041009078 @default.
- W1485179699 cites W2041404362 @default.
- W1485179699 cites W2047366876 @default.
- W1485179699 cites W2058582479 @default.
- W1485179699 cites W2063109954 @default.
- W1485179699 cites W2072114342 @default.
- W1485179699 cites W2074778496 @default.
- W1485179699 cites W2077602130 @default.
- W1485179699 cites W2077812123 @default.
- W1485179699 cites W2082950857 @default.
- W1485179699 cites W2084147966 @default.
- W1485179699 cites W2090835365 @default.
- W1485179699 cites W2092128665 @default.
- W1485179699 cites W2093942918 @default.
- W1485179699 cites W2094336084 @default.
- W1485179699 cites W2101634316 @default.
- W1485179699 cites W2103858336 @default.
- W1485179699 cites W2105808377 @default.
- W1485179699 cites W2107860814 @default.
- W1485179699 cites W2114213433 @default.
- W1485179699 cites W2117761826 @default.
- W1485179699 cites W2121602918 @default.
- W1485179699 cites W2134453100 @default.
- W1485179699 cites W2139721879 @default.
- W1485179699 cites W2149160053 @default.
- W1485179699 cites W2154999402 @default.
- W1485179699 cites W2169293700 @default.
- W1485179699 cites W2187691537 @default.
- W1485179699 cites W4313313458 @default.
- W1485179699 cites W4313422262 @default.
- W1485179699 doi "https://doi.org/10.4049/jimmunol.164.11.5683" @default.
- W1485179699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10820244" @default.
- W1485179699 hasPublicationYear "2000" @default.
- W1485179699 type Work @default.
- W1485179699 sameAs 1485179699 @default.
- W1485179699 citedByCount "146" @default.
- W1485179699 countsByYear W14851796992012 @default.
- W1485179699 countsByYear W14851796992013 @default.
- W1485179699 countsByYear W14851796992014 @default.
- W1485179699 countsByYear W14851796992015 @default.
- W1485179699 countsByYear W14851796992016 @default.
- W1485179699 countsByYear W14851796992020 @default.
- W1485179699 countsByYear W14851796992021 @default.
- W1485179699 countsByYear W14851796992022 @default.
- W1485179699 countsByYear W14851796992023 @default.
- W1485179699 crossrefType "journal-article" @default.
- W1485179699 hasAuthorship W1485179699A5005119540 @default.
- W1485179699 hasAuthorship W1485179699A5012998783 @default.
- W1485179699 hasAuthorship W1485179699A5039903543 @default.
- W1485179699 hasBestOaLocation W14851796991 @default.
- W1485179699 hasConcept C100701293 @default.
- W1485179699 hasConcept C104317684 @default.
- W1485179699 hasConcept C140173407 @default.
- W1485179699 hasConcept C150194340 @default.
- W1485179699 hasConcept C185592680 @default.
- W1485179699 hasConcept C190727270 @default.
- W1485179699 hasConcept C203014093 @default.
- W1485179699 hasConcept C207001950 @default.
- W1485179699 hasConcept C22801619 @default.
- W1485179699 hasConcept C51785407 @default.
- W1485179699 hasConcept C54355233 @default.
- W1485179699 hasConcept C55493867 @default.
- W1485179699 hasConcept C59822182 @default.
- W1485179699 hasConcept C81444415 @default.
- W1485179699 hasConcept C86803240 @default.
- W1485179699 hasConcept C95444343 @default.
- W1485179699 hasConceptScore W1485179699C100701293 @default.