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• W1485192022 abstract "The eukaryotic filamentous fungus Neurospora crassa is a tractable model system that has provided numerous insights into the molecular basis of circadian rhythms. In the core circadian clock feedback loop, WC-1 and WC-2 interact via PAS domains to heterodimerize, and this complex acts both as the circadian photoreceptor and, in the dark, as a transcription factor that promotes the expression of the frq gene. In the negative step of the loop, dimers of FRQ feed back to block the activity of the WC-1/WC-2 complex (WCC) and, in a positive step, to promote the synthesis of WC-1. Several kinases phosphorylate FRQ, leading to its ubiquitination and turnover, releasing the WC-1/WC-2 dimer to reactivate frq expression and restart the circadian cycle. Light and temperature entrainment of the clock arise from rapid light induction of frq expression and from the effect of elevated temperatures in driving higher levels of FRQ. Noncircadian candidate slave oscillators, termed FRQ-less oscillators (FLOs), have been described, each of which appears to regulate aspects of Neurospora growth or development. Overall, the core FRQ/WCC feedback loop coordinates the circadian system by regulating downstream clock-controlled genes either directly or via regulation of driven FLOs. This article provides a brief synopsis of the system and describes current assays for the Neurospora clock. Methods for genetic and molecular manipulation of the core clock are summarized, and accompanying chapters address more specifically aspects of photobiology and output." @default.
• W1485192022 created "2016-06-24" @default.
• W1485192022 creator A5012555968 @default.
• W1485192022 creator A5028655150 @default.
• W1485192022 date "2005-01-01" @default.
• W1485192022 modified "2023-09-23" @default.
• W1485192022 title "Analysis of Circadian Rhythms in Neurospora: Overview of Assays and Genetic and Molecular Biological Manipulation" @default.
• W1485192022 cites W1519387955 @default.
• W1485192022 cites W1545198469 @default.
• W1485192022 cites W1577745292 @default.
• W1485192022 cites W1891211155 @default.
• W1485192022 cites W1904305605 @default.
• W1485192022 cites W1962384043 @default.
• W1485192022 cites W1967095822 @default.
• W1485192022 cites W1976971664 @default.
• W1485192022 cites W1984709672 @default.
• W1485192022 cites W1985078116 @default.
• W1485192022 cites W1987216903 @default.
• W1485192022 cites W1990210226 @default.
• W1485192022 cites W1994880500 @default.
• W1485192022 cites W1996625174 @default.
• W1485192022 cites W1998418064 @default.
• W1485192022 cites W1998999712 @default.
• W1485192022 cites W2004558957 @default.
• W1485192022 cites W2005811101 @default.
• W1485192022 cites W2006280763 @default.
• W1485192022 cites W2006716390 @default.
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• W1485192022 cites W2007885546 @default.
• W1485192022 cites W2008319728 @default.
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• W1485192022 cites W2027456443 @default.
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• W1485192022 cites W2042027518 @default.
• W1485192022 cites W2042068133 @default.
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• W1485192022 doi "https://doi.org/10.1016/s0076-6879(05)93001-2" @default.
• W1485192022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15817284" @default.
• W1485192022 hasPublicationYear "2005" @default.
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