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- W1485192733 abstract "Abstract Rabbit liver mitochondria incubated in a basic medium containing pyruvate, bicarbonate, MgSO4, and Pi synthesize and liberate to the medium malate, citrate, and also aspartate (provided NH4+ is included in the medium). Only a minor amount of P-enolpyruvate is formed and liberated under these same conditions. Substrate utilization and especially metabolite production are dependent on exogenous Pi and also quite dependent on exogenous bicarbonate. Exogenous ATP inhibits substrate utilization and especially inhibits total metabolite formation. Mitochondria from 48-hour fasted rabbits or from fed alloxan diabetic rabbits as contrasted to those from normal fed rabbits appear to use more pyruvate and to synthesize significantly greater amounts of P-enolpyruvate and malate. The amounts of P-enolpyruvate formed, although larger, are still extremely small and considered insufficient to satisfy the rabbit's requirements for glucose. Cytosol prepared from livers of normal fed rabbits contain a measurable amount of P-enolpyruvate carboxykinase; cytosol from livers of fasted or alloxan diabetic rabbits contain substantially greater quantities this enzyme. Refeeding of fasted rabbits diminishes the cytosolic content of carboxykinase to near normal levels. Distribution studies with cytochrome oxidase and citrate synthetase as marker enzymes confirm the in vivo existence of P-enolpyruvate carboxykinase in rabbit liver cytosol. Cytosolic malate dehydrogenase, aspartate aminotransferase, and fumarate dehydratase activities, generally speaking, respond very little to alterations in nutritional states which substantially affect cytosolic carboxykinase. These data support the concept that cytosolic P-enolpyruvate carboxykinase can contribute significantly to gluconeogenesis in this species." @default.
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- W1485192733 date "1973-02-01" @default.
- W1485192733 modified "2023-10-12" @default.
- W1485192733 title "Gluconeogenesis in Rabbit Liver" @default.
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- W1485192733 doi "https://doi.org/10.1016/s0021-9258(19)44333-0" @default.
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