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- W1485232123 abstract "Groups of three dogs were given single inhalation exposures to dry aerosols of one of four different plutonium dioxides to compare retention, translocation, and rates of excretion. Two of the plutonium dioxides were prepared by calcining the oxalate at 350°C and at about 1000°C. Two others were produced by ignition of the stabilized delta metal at 450°C and by slow oxidation of the pure metal at 123°C. The lung retention half-time of the oxalate calcined at 350°C was about one year, half that of the other oxides. This was due to greater accumulation of plutonium in the bronchial lymph nodes rather than greater clearance via the mucus-ciliary pathway or a relatively high rate of solubility. The metal oxidized at 450°C was cleared via the mucus-ciliary route to a lesser extent than the other oxides. This same oxide also showed a selective loss of 241Am, relative to 239Pu, in lung and bronchial lymph node tissue which was not evidenced by the other oxides. The oxalate calcined at 1000°C showed the least translocation to tissues outside the respiratory tract. These results indicate that the physical-chemical state of inhaled plutonium dioxide influences its disposition in the body." @default.
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- W1485232123 date "1968-01-01" @default.
- W1485232123 modified "2023-09-23" @default.
- W1485232123 title "COMPARATIVE DISPOSITION OF FOUR TYPES OF PLUTONIUM DIOXIDES INHALED BY DOGS" @default.
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- W1485232123 doi "https://doi.org/10.1016/b978-1-4832-8312-8.50034-5" @default.
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