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• W1485316010 abstract "The aim of this study was to evaluate micafungin efficacy for treatment of invasive candidiasis/candidaemia in patients with cancer. Modified intent-to-treat populations were analysed from two trials: one, in adults and children with confirmed Candida infection, compared micafungin (adults 100 mg day−1; children 2 mg kg−1 day−1) with liposomal amphotericin B (L-AmB 3 mg kg−1 day−1); and the other, in adults only, compared micafungin (100 or 150 mg day−1) with caspofungin (50 mg day−1; 70 mg loading dose). Primary efficacy endpoint in both trials was treatment success, defined as both clinical and mycological response at end of therapy. In the micafungin/L-AmB trial, 183/489 patients had malignancy (37% neutropenic). In the micafungin/caspofungin trial, 176/572 patients had malignancy (26% neutropenic). Micafungin treatment success rates were generally similar in patients with/without malignancy and to rates observed with L-AmB and caspofungin. Most patients with malignancy and neutropenia were successfully treated by all three drugs. For all drugs, incidence of discontinuations because of treatment-related adverse events was similar for patients with malignancy (≤7.7%) vs. no malignancy (≤8.0%). These results suggest that compared with L-AmB and caspofungin, micafungin was effective and well tolerated in patients with candidiasis/candidaemia with/without malignancy. Further prospective trials are recommended to evaluate comparative outcomes with a primary focus on patients with malignancies and invasive candidiasis." @default.
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• W1485316010 date "2011-06-13" @default.
• W1485316010 modified "2023-10-18" @default.
• W1485316010 title "Efficacy and safety of micafungin for treatment of serious Candida infections in patients with or without malignant disease" @default.
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• W1485316010 doi "https://doi.org/10.1111/j.1439-0507.2011.02045.x" @default.
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