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• W1485354490 abstract "The extracellular matrix exerts profound effects on both cell movement and cell differentiation during development. The influences of the matrix are integrated with those of the differentiative lineage program of the cell, and with the cell-to-cell interactions that occur during morphogenesis. The matrix itself is composed of an array of multidomain glycoproteins, including fibronectin and various collagens, which form an integrated extracellular environment that has both permissive and informational roles in cell movement and differentiation. Basement membranes are specialized regions of the matrix that serve a number of roles, including the maintenance of epithelial polarity, acting as a substratum for cell movement, and in the mediation of epithelial-mesenchymal inductive interactions. The extracellular matrix is subject to developmental regulation in that its composition can be shown to vary during different phases of development. Cells are able to respond to changes in the extracellular matrix by means of cell surface receptors, including the transmembrane integrins and plasma membrane-associated proteoglycans such as heparan sulfate proteoglycan. Signals from the matrix are transduced such into the cell via transmembrane complexes that are linked at the cytoplasmic face to elements of the cystoskeleton. Evidence is also accumulating for the participation of second messenger pathways in the signal transduction pathways are poorly understood at present. 0130 0154V 3" @default.
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• W1485354490 date "1998-01-01" @default.
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• W1485354490 title "Chapter 5 The role of extracellular matrix during development" @default.
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• W1485354490 doi "https://doi.org/10.1016/s1569-2582(98)80020-2" @default.
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