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- W1485381775 abstract "Abstract Background and Aim Genetic polymorphism has been implicated as a factor for the occurrence of non‐alcoholic fatty liver disease ( NAFLD ). This study attempted to assess whether polymorphisms in the leptin receptor ( LEPR ) gene and its combined effect with patatin‐like phospholipase domain‐containing protein 3 ( PNPLA3 /adiponutrin) are associated with risk of NAFLD . Methods A total of 144 biopsy‐proven NAFLD and 198 controls were genotyped using the Sequenom MassARRAY platform. Results We observed a significant association between the LEPR rs1137100 and rs1137101 with susceptibility to NAFLD (odds ratio [ OR ] 1.64, 95% confidence interval [ CI ] 1.18–2.28, P = 0.003; and OR 1.61, 95% CI 1.11–2.34, P = 0.013, respectively) and to non‐alcoholic steatohepatitis ( OR 1.49, 95% CI 1.05–2.12, P = 0.026; and OR 1.57, 95% CI 1.05–2.35, P = 0.029, respectively). The LEPR rs1137100 is also associated with simple steatosis ( OR 2.27, 95% CI 1.27–4.08, P = 0.006). Analysis of gene–gene interaction revealed a strong interaction between the LEPR and PNPLA3 genes (empirical P = 0.001). The joint effect of LEPR and PNPLA3 greatly exacerbated the risk of NAFLD ( OR 3.73, 95% CI 1.84–7.55, P < 0.0001). The G allele of rs1137100 is associated with lower fibrosis score ( OR 0.47, 95% CI 0.28–0.78, P = 0.001). Conclusions We report an association between variants of LEPR rs1137100 and rs1137101 with risk of NAFLD . This study suggests that rs1137100, specifically the G allele, is associated with a less severe form of liver disease in patients with NAFLD . The interaction between LEPR and PNPLA3 genes showed increased risk of NAFLD compared to either gene alone." @default.
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- W1485381775 date "2013-04-25" @default.
- W1485381775 modified "2023-10-17" @default.
- W1485381775 title "Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene" @default.
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- W1485381775 doi "https://doi.org/10.1111/jgh.12104" @default.
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