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- W1485401597 abstract "Eukaryotic cells contain a variety of cytoplasmic Ca(2+)-dependent and Ca(2+)-independent phospholipase A2s (PLA2s; EC 2.3.1.2.3). However, the physiological roles for many of these ubiquitously-expressed enzymes is unclear or not known. Recently, pharmacological studies have suggested a role for Ca(2+)-independent PLA2 (iPLA2) enzymes in governing intracellular membrane trafficking events in general and regulating brefeldin A (BFA)-stimulated membrane tubulation and Golgi-to-endoplasmic reticulum (ER) retrograde membrane trafficking, in particular. Here, we extend these studies to show that membrane-permeant iPLA2 antagonists potently inhibit the normal, constitutive retrograde membrane trafficking from the trans-Golgi network (TGN), Golgi complex, and the ERGIC-53-positive ER-Golgi-intermediate compartment (ERGIC), which occurs in the absence of BFA. Taken together, these results suggest that iPLA2 enzymes play a general role in regulating, or directly mediating, multiple mammalian membrane trafficking events." @default.
- W1485401597 created "2016-06-24" @default.
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- W1485401597 date "2000-06-01" @default.
- W1485401597 modified "2023-10-18" @default.
- W1485401597 title "Phospholipase A2 Antagonists Inhibit Constitutive Retrograde Membrane Traffic to the Endoplasmic Reticulum" @default.
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- W1485401597 doi "https://doi.org/10.1034/j.1600-0854.2000.010608.x" @default.
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