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- W1485449238 abstract "In order to identify the active principles in the 50% MeOH extract of the Chinese crude drug Chang Zhu (consisting of Atractylodes lancea rhizome), which has a preventive activity against experimental ulcerations, the effects of the benzene, methanol and aqueous fractions from 50% MeOH extract on gastric secretion in pylorus-ligated rats were investigated.The terpenes, β-eudesmol and hinesol, contained in benzene fraction were found to be highly effective. β-Eudesmol markedly inhibited ulcers in Shay rats, as well as histamine- and aspirin-induced gastric ulcers, and showed anti-secretory activity on gastric acid secretion stimulated by histamine in a perfused rat stomach preparation.The anti-ulcerogenic activity of 50% MeOH extract of Atractylodes lancea rhizome might be mainly attributable to the H2-antagonistic effect of β-eudesmol." @default.
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- W1485449238 date "1986-01-01" @default.
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- W1485449238 title "Studies on the origin, processing and quality of crude drugs. II Pharmacological evaluation of the Chinese crude drug Zhu in experimental stomach ulcer. 2 Inhibitory effect of extract of Atractylodes lancea on gastric secretion." @default.
- W1485449238 doi "https://doi.org/10.1248/cpb.34.3854" @default.
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