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- W1485573359 abstract "This review examines the utility of flexible bronchoscopy (FB) in paediatric lung transplant recipients and other immunosuppressed children, including indications and contraindications, risk-benefits and potential complications of bronchoalveolar lavage (BAL) and transbronchial biopsy (TBB). FB with BAL/TBB is a valuable tool to establish the presence or absence of acute lung allograft rejection and/or infection that provides a high sensitivity and specificity; however, bronchiolitis obliterans (BO) is less well diagnosed. FB with BAL/TBB can be carried out safely with a good yield. The complication rate of the procedure is low. FB is clinically indicated in every symptomatic paediatric lung transplant recipient. The majority of paediatric centres perform regularly scheduled surveillance bronchoscopies with BAL/TBB, aiming to reduce the incidence of BO by earlier detection of acute rejection or infection and to target therapy; however, it is not clear whether surveillance bronchoscopy improves long-term posttransplantation survival. The role of FB in other immunosuppressed children with pulmonary complications is less well defined, but the technique is valuable in identifying infection and thus guiding treatment. Immunosuppressed patients are often highly symptomatic and sometimes in borderline respiratory failure; therefore, the potential risk-benefit profile of FB has to be assessed first." @default.
- W1485573359 created "2016-06-24" @default.
- W1485573359 creator A5031494467 @default.
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- W1485573359 date "2010-01-01" @default.
- W1485573359 modified "2023-09-26" @default.
- W1485573359 title "Lung Transplant Recipients and Other Immunosuppressed Patients" @default.
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- W1485573359 doi "https://doi.org/10.1159/000314397" @default.
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