Matches in SemOpenAlex for { <https://semopenalex.org/work/W1485615377> ?p ?o ?g. }
- W1485615377 abstract "Growing evidence supports an active role for deregulated macroautophagy (autophagic stress) in neuronal cell death and neurodegenerative diseases, as Parkinson’s disease (PD). The exact etiology of PD is currently unknown, but it seems clear that its pathogenesis is a multifactorial process. The detection of genetic alterations may be useful as a biomarker of early molecular diagnosis, but it is also important to know and identify changes at the molecular level, more frequent in cases of Parkinsonism. In this sense, the phenomenon of autophagic cell death, described in the normal nervous system, could be the result of a pathological process, such as those related to neurodegenerative diseases. Autophagy is an intracellular catabolic mecha‐ nism mediated by lysosomes, which is responsible for most of the degradation and recycling of cytoplasmic components and intracellular organelles dysfunctional or damaged. For a long time, it is unknown why the aggregation of proteins and developmental neurotoxicity are given in a later period of life, even in familial forms of the disease, where the mutant protein is present throughout life in the individual. It has been shown that genetic ablation of autoph‐ agy induces neurodegeneration and accumulation of ubiquitinated proteins. In addition, some genetic mutations that cause neurodegenerative diseases directly affect proteolytic systems responsible for the degradation of the mutant protein. In this paper, we analyze the possible neuroprotective role that autophagy-inducing substances can have on the mechanism and development of PD." @default.
- W1485615377 created "2016-06-24" @default.
- W1485615377 creator A5009372799 @default.
- W1485615377 creator A5009424114 @default.
- W1485615377 creator A5020171607 @default.
- W1485615377 creator A5064871210 @default.
- W1485615377 creator A5066273581 @default.
- W1485615377 creator A5069736347 @default.
- W1485615377 creator A5080052880 @default.
- W1485615377 date "2013-01-23" @default.
- W1485615377 modified "2023-09-27" @default.
- W1485615377 title "Autophagy: A Possible Defense Mechanism in Parkinson's Disease?" @default.
- W1485615377 cites W149565960 @default.
- W1485615377 cites W1527671059 @default.
- W1485615377 cites W1548494899 @default.
- W1485615377 cites W1577928045 @default.
- W1485615377 cites W1591724033 @default.
- W1485615377 cites W1630502818 @default.
- W1485615377 cites W1724227103 @default.
- W1485615377 cites W178935525 @default.
- W1485615377 cites W1877873625 @default.
- W1485615377 cites W1930159471 @default.
- W1485615377 cites W1954514489 @default.
- W1485615377 cites W1968322176 @default.
- W1485615377 cites W1968444524 @default.
- W1485615377 cites W1969611373 @default.
- W1485615377 cites W1977267085 @default.
- W1485615377 cites W1977430596 @default.
- W1485615377 cites W1978071667 @default.
- W1485615377 cites W1978285826 @default.
- W1485615377 cites W1980854786 @default.
- W1485615377 cites W1981144487 @default.
- W1485615377 cites W1982221081 @default.
- W1485615377 cites W1982460960 @default.
- W1485615377 cites W1983698019 @default.
- W1485615377 cites W1983833627 @default.
- W1485615377 cites W1984423498 @default.
- W1485615377 cites W1990387678 @default.
- W1485615377 cites W1991105254 @default.
- W1485615377 cites W1991804565 @default.
- W1485615377 cites W1992998321 @default.
- W1485615377 cites W1993467627 @default.
- W1485615377 cites W1999187119 @default.
- W1485615377 cites W2001180390 @default.
- W1485615377 cites W2002599143 @default.
- W1485615377 cites W2002635963 @default.
- W1485615377 cites W2005736754 @default.
- W1485615377 cites W2005853389 @default.
- W1485615377 cites W2006257297 @default.
- W1485615377 cites W2006559495 @default.
- W1485615377 cites W2007635429 @default.
- W1485615377 cites W2008886854 @default.
- W1485615377 cites W2010277507 @default.
- W1485615377 cites W2011733849 @default.
- W1485615377 cites W2013944211 @default.
- W1485615377 cites W2016794759 @default.
- W1485615377 cites W2019347164 @default.
- W1485615377 cites W2019817056 @default.
- W1485615377 cites W2019895460 @default.
- W1485615377 cites W2021766187 @default.
- W1485615377 cites W2022034337 @default.
- W1485615377 cites W2025205297 @default.
- W1485615377 cites W2025931289 @default.
- W1485615377 cites W2027096397 @default.
- W1485615377 cites W2027098023 @default.
- W1485615377 cites W2028622306 @default.
- W1485615377 cites W2029059439 @default.
- W1485615377 cites W2030667534 @default.
- W1485615377 cites W2031837514 @default.
- W1485615377 cites W2032379590 @default.
- W1485615377 cites W2033064740 @default.
- W1485615377 cites W2037437861 @default.
- W1485615377 cites W2038557175 @default.
- W1485615377 cites W2043543810 @default.
- W1485615377 cites W2044156447 @default.
- W1485615377 cites W2044407202 @default.
- W1485615377 cites W2044537731 @default.
- W1485615377 cites W2047501420 @default.
- W1485615377 cites W2048033372 @default.
- W1485615377 cites W2049359499 @default.
- W1485615377 cites W2049613365 @default.
- W1485615377 cites W2049800884 @default.
- W1485615377 cites W2050647292 @default.
- W1485615377 cites W2053716193 @default.
- W1485615377 cites W2054561574 @default.
- W1485615377 cites W2055308573 @default.
- W1485615377 cites W2057220764 @default.
- W1485615377 cites W2065236536 @default.
- W1485615377 cites W2065949544 @default.
- W1485615377 cites W2066817189 @default.
- W1485615377 cites W2068015577 @default.
- W1485615377 cites W2068288454 @default.
- W1485615377 cites W2068336834 @default.
- W1485615377 cites W2068383276 @default.
- W1485615377 cites W2072334716 @default.
- W1485615377 cites W2072417584 @default.
- W1485615377 cites W2073449985 @default.
- W1485615377 cites W2076743021 @default.
- W1485615377 cites W2077260129 @default.
- W1485615377 cites W2077567337 @default.