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- W1485658052 abstract "Abstract : - A manufacturing protocol for JO-1 with and without His-tag at large scale has been established. - There were no adverse effects after intravenous injection of JO-1 in DSG2 transgenic mice. - JO-1 has favorable pharmacokinetics parameters. - The effect of JO-1 on normal tissues is minimal because DSG2 is trapped in epithelial junctions in normal tissues and not accessible to intravenously injected JO-1. - JO-1 enhances Doxil chemotherapy in xenograft models of ovarian cancer and in mouse models with syngeneic tumors. - JO-1 continues to be effective after multiple treatment cycles even in the presence of detectable antibodies. - JO-1 facilitates pre-existing anti-tumor T-cell responses. - An affinity-enhanced version of JO-1 (called JO-4) was produced. - JO-4 co-therapy allows for reduction of effective Doxil dose in a xenograft model of ovarian cancer. - JO-4 increases the therapeutic effect of Doxil on lymphogenic metastases. - Combined treatment with JO-4 and Doxil is safe in non-human primates" @default.
- W1485658052 created "2016-06-24" @default.
- W1485658052 creator A5029285661 @default.
- W1485658052 date "2013-10-01" @default.
- W1485658052 modified "2023-09-27" @default.
- W1485658052 title "A Combination Therapy of JO-I and Chemotherapy in Ovarian Cancer Models" @default.
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- W1485658052 doi "https://doi.org/10.21236/ada598401" @default.
- W1485658052 hasPublicationYear "2013" @default.
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