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• W1485698702 abstract "We describe a new synthesis of the 5-(aminomethyl)oxazolidin-3-one core of linezolid in enantiomerically pure form. The expedient cyclization of the α-hydroxy amide derived from isoserine and 3-fluoro-4-morpholinoaniline to give the corresponding (aminomethyl)oxazolidine-2,4-dione, followed by its mild selective reduction at the C(4)-position, gave linezolid in almost quantitative overall yield." @default.
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• W1485698702 date "2014-10-28" @default.
• W1485698702 modified "2023-09-23" @default.
• W1485698702 title "Convenient Synthesis of the Antibiotic Linezolid via an Oxazolidine-2,4-dione Intermediate Derived from the Chiral Building Block Isoserine" @default.
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• W1485698702 doi "https://doi.org/10.1002/ejoc.201402888" @default.
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