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- W1485755392 abstract "Nicotinic acetylcholine receptors (nAChRs) fulfill a variety of functions making identification and analysis of nAChR subtypes a challenging task. Traditional instruments for nAChR research are d-tubocurarine, snake venom protein α-bungarotoxin (α-Bgt), and α-conotoxins, neurotoxic peptides from Conus snails. Various new compounds of different structural classes also interacting with nAChRs have been recently identified. Among the low-molecular weight compounds are alkaloids pibocin, varacin and makaluvamines C and G. 6-Bromohypaphorine from the mollusk Hermissenda crassicornis does not bind to Torpedo nAChR but behaves as an agonist on human α7 nAChR. To get more selective α-conotoxins, computer modeling of their complexes with acetylcholine-binding proteins and distinct nAChRs was used. Several novel three-finger neurotoxins targeting nAChRs were described and α-Bgt inhibition of GABA-A receptors was discovered. Information on the mechanisms of nAChR interactions with the three-finger proteins of the Ly6 family was found. Snake venom phospholipases A2 were recently found to inhibit different nAChR subtypes. Blocking of nAChRs in Lymnaea stagnalis neurons was shown for venom C-type lectin-like proteins, appearing to be the largest molecules capable to interact with the receptor. A huge nAChR molecule sensible to conformational rearrangements accommodates diverse binding sites recognizable by structurally very different compounds." @default.
- W1485755392 created "2016-06-24" @default.
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- W1485755392 date "2015-05-14" @default.
- W1485755392 modified "2023-10-18" @default.
- W1485755392 title "Natural Compounds Interacting with Nicotinic Acetylcholine Receptors: From Low-Molecular Weight Ones to Peptides and Proteins" @default.
- W1485755392 cites W1496436965 @default.
- W1485755392 cites W1788430178 @default.
- W1485755392 cites W1904864670 @default.
- W1485755392 cites W1959442511 @default.
- W1485755392 cites W1963909584 @default.
- W1485755392 cites W1965265774 @default.
- W1485755392 cites W1965396559 @default.
- W1485755392 cites W1968618363 @default.
- W1485755392 cites W1969591490 @default.
- W1485755392 cites W1971241165 @default.
- W1485755392 cites W1971356928 @default.
- W1485755392 cites W1974958755 @default.
- W1485755392 cites W1975040108 @default.
- W1485755392 cites W1975239375 @default.
- W1485755392 cites W1976555554 @default.
- W1485755392 cites W1978980201 @default.
- W1485755392 cites W1980345684 @default.
- W1485755392 cites W1981122771 @default.
- W1485755392 cites W1982371070 @default.
- W1485755392 cites W1983761344 @default.
- W1485755392 cites W1985194591 @default.
- W1485755392 cites W1986453975 @default.
- W1485755392 cites W1988508746 @default.
- W1485755392 cites W1990727262 @default.
- W1485755392 cites W1991614835 @default.
- W1485755392 cites W1995301920 @default.
- W1485755392 cites W1995989957 @default.
- W1485755392 cites W1996714203 @default.
- W1485755392 cites W1997107096 @default.
- W1485755392 cites W1997901145 @default.
- W1485755392 cites W2000001823 @default.
- W1485755392 cites W2000523303 @default.
- W1485755392 cites W2003675844 @default.
- W1485755392 cites W2006974629 @default.
- W1485755392 cites W2008039943 @default.
- W1485755392 cites W2010022125 @default.
- W1485755392 cites W2010646554 @default.
- W1485755392 cites W2011510017 @default.
- W1485755392 cites W2013480966 @default.
- W1485755392 cites W2013613444 @default.
- W1485755392 cites W2015273486 @default.
- W1485755392 cites W2016397546 @default.
- W1485755392 cites W2018191744 @default.
- W1485755392 cites W2022027361 @default.
- W1485755392 cites W2022517656 @default.
- W1485755392 cites W2023259110 @default.
- W1485755392 cites W2023435849 @default.
- W1485755392 cites W2027462994 @default.
- W1485755392 cites W2028238530 @default.
- W1485755392 cites W2033140682 @default.
- W1485755392 cites W2034074020 @default.
- W1485755392 cites W2034611969 @default.
- W1485755392 cites W2035074554 @default.
- W1485755392 cites W2041331908 @default.
- W1485755392 cites W2041720100 @default.
- W1485755392 cites W2042890168 @default.
- W1485755392 cites W2042979741 @default.
- W1485755392 cites W2043610985 @default.
- W1485755392 cites W2044486145 @default.
- W1485755392 cites W2044790426 @default.
- W1485755392 cites W2045540781 @default.
- W1485755392 cites W2048038345 @default.
- W1485755392 cites W2048457764 @default.
- W1485755392 cites W2053870022 @default.
- W1485755392 cites W2055865789 @default.
- W1485755392 cites W2058976078 @default.
- W1485755392 cites W2059230624 @default.
- W1485755392 cites W2061543974 @default.
- W1485755392 cites W2062720349 @default.
- W1485755392 cites W2064460213 @default.
- W1485755392 cites W2065897426 @default.
- W1485755392 cites W2068481297 @default.
- W1485755392 cites W2070134886 @default.
- W1485755392 cites W2070740144 @default.
- W1485755392 cites W2072517445 @default.
- W1485755392 cites W2074700931 @default.
- W1485755392 cites W2080781079 @default.
- W1485755392 cites W2081817431 @default.
- W1485755392 cites W2083489577 @default.
- W1485755392 cites W2083793132 @default.
- W1485755392 cites W2085461397 @default.
- W1485755392 cites W2085913208 @default.
- W1485755392 cites W2087175476 @default.