FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1485946719> ?p ?o ?g. }

• W1485946719 endingPage "4487" @default.
• W1485946719 startingPage "4478" @default.
• W1485946719 abstract "The MHC has genetic associations with many diseases, often due to differences in presentation of antigenic peptides by polymorphic MHC molecules to T lymphocytes of the immune system. In chickens, only a single classical class I molecule in each MHC haplotype is expressed well due to coevolution with the polymorphic TAPs which means that resistance and susceptibility to infectious pathogens are particularly easy to observe. Previously, structures of chicken MHC class I molecule BF2*2101 from B21 haplotype showed an unusually large peptide-binding groove that accommodates a broad spectrum of peptides to present as epitopes to CTLs, explaining the MHC-determined resistance of B21 chickens to Marek's disease. In this study, we report the crystal structure of BF2*0401 from the B4 (also known as B13) haplotype, showing a highly positively charged surface hitherto unobserved in other MHC molecules, as well as a remarkably narrow groove due to the allele-specific residues with bulky side chains. Together, these properties limit the number of epitope peptides that can bind this class I molecule. However, peptide-binding assays show that in vitro, BF2*0401 can bind a wider variety of peptides than are found on the surface of B4 cells. Thus, a combination of the specificities of the polymorphic TAP and the MHC results in a very limited set of BF2*0401 peptides with negatively charged anchors to be presented to T lymphocytes." @default.
• W1485946719 created "2016-06-24" @default.
• W1485946719 creator A5000987583 @default.
• W1485946719 creator A5009801938 @default.
• W1485946719 creator A5015873777 @default.
• W1485946719 creator A5027835055 @default.
• W1485946719 creator A5035893335 @default.
• W1485946719 creator A5041969299 @default.
• W1485946719 creator A5049165439 @default.
• W1485946719 creator A5072284526 @default.
• W1485946719 creator A5085462851 @default.
• W1485946719 creator A5087385265 @default.
• W1485946719 date "2012-11-01" @default.
• W1485946719 modified "2023-10-08" @default.
• W1485946719 title "Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens" @default.
• W1485946719 cites W1536083038 @default.
• W1485946719 cites W1539796472 @default.
• W1485946719 cites W1634772899 @default.
• W1485946719 cites W1965132632 @default.
• W1485946719 cites W1967253926 @default.
• W1485946719 cites W1971141213 @default.
• W1485946719 cites W1979859097 @default.
• W1485946719 cites W1982273478 @default.
• W1485946719 cites W1992260258 @default.
• W1485946719 cites W1995506240 @default.
• W1485946719 cites W1999169049 @default.
• W1485946719 cites W2000626299 @default.
• W1485946719 cites W2001641653 @default.
• W1485946719 cites W2006995093 @default.
• W1485946719 cites W2016255772 @default.
• W1485946719 cites W2019792235 @default.
• W1485946719 cites W2019993505 @default.
• W1485946719 cites W2036704641 @default.
• W1485946719 cites W2037361354 @default.
• W1485946719 cites W2038840577 @default.
• W1485946719 cites W2048931419 @default.
• W1485946719 cites W2051599163 @default.
• W1485946719 cites W2060736209 @default.
• W1485946719 cites W2073621589 @default.
• W1485946719 cites W2073883777 @default.
• W1485946719 cites W2076058809 @default.
• W1485946719 cites W2076632783 @default.
• W1485946719 cites W2108981718 @default.
• W1485946719 cites W2120434612 @default.
• W1485946719 cites W2131363383 @default.
• W1485946719 cites W2134054751 @default.
• W1485946719 cites W2134201060 @default.
• W1485946719 cites W2134830418 @default.
• W1485946719 cites W2143856741 @default.
• W1485946719 cites W2144081223 @default.
• W1485946719 cites W2155740919 @default.
• W1485946719 cites W2156765158 @default.
• W1485946719 cites W2159404298 @default.
• W1485946719 cites W2162970494 @default.
• W1485946719 cites W2164094488 @default.
• W1485946719 cites W2166944987 @default.
• W1485946719 cites W2320310474 @default.
• W1485946719 cites W2762980752 @default.
• W1485946719 doi "https://doi.org/10.4049/jimmunol.1200885" @default.
• W1485946719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5018395" @default.
• W1485946719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23041567" @default.
• W1485946719 hasPublicationYear "2012" @default.
• W1485946719 type Work @default.
• W1485946719 sameAs 1485946719 @default.
• W1485946719 citedByCount "49" @default.
• W1485946719 countsByYear W14859467192013 @default.
• W1485946719 countsByYear W14859467192014 @default.
• W1485946719 countsByYear W14859467192015 @default.
• W1485946719 countsByYear W14859467192016 @default.
• W1485946719 countsByYear W14859467192017 @default.
• W1485946719 countsByYear W14859467192018 @default.
• W1485946719 countsByYear W14859467192020 @default.
• W1485946719 countsByYear W14859467192021 @default.
• W1485946719 countsByYear W14859467192022 @default.
• W1485946719 countsByYear W14859467192023 @default.
• W1485946719 crossrefType "journal-article" @default.
• W1485946719 hasAuthorship W1485946719A5000987583 @default.
• W1485946719 hasAuthorship W1485946719A5009801938 @default.
• W1485946719 hasAuthorship W1485946719A5015873777 @default.
• W1485946719 hasAuthorship W1485946719A5027835055 @default.
• W1485946719 hasAuthorship W1485946719A5035893335 @default.
• W1485946719 hasAuthorship W1485946719A5041969299 @default.
• W1485946719 hasAuthorship W1485946719A5049165439 @default.
• W1485946719 hasAuthorship W1485946719A5072284526 @default.
• W1485946719 hasAuthorship W1485946719A5085462851 @default.
• W1485946719 hasAuthorship W1485946719A5087385265 @default.
• W1485946719 hasBestOaLocation W14859467191 @default.
• W1485946719 hasConcept C104317684 @default.
• W1485946719 hasConcept C147483822 @default.
• W1485946719 hasConcept C170627219 @default.
• W1485946719 hasConcept C180754005 @default.
• W1485946719 hasConcept C195616568 @default.
• W1485946719 hasConcept C197695756 @default.
• W1485946719 hasConcept C197754878 @default.
• W1485946719 hasConcept C207936829 @default.
• W1485946719 hasConcept C22845430 @default.
• W1485946719 hasConcept C2776090121 @default.
• W1485946719 hasConcept C2778814158 @default.

• next