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- W148594990 abstract "In patients with carotid or middle cerebral artery occlusive disease, the cerebral blood flow downstream from the arterial obstruction will depend on the adequacy of the collateral circulation. Oxygen extraction fraction (OEF) will increase as a compensatory response to maintain cerebral oxygen metabolism when the collateral pathways are insufficient to maintain CBF at a normal level but still adequate to provide sufficient flow to prevent cerebral infarction. Positron emission tomography permits the measurement of regional OEF in humans and can identify patients with symptomatic carotid or middle cerebral artery occlusive disease who are at high risk for subsequent stroke. Extracranial–intracranial bypass surgery can improve CBF distal to the obstruction return, OEF toward normal, and reduce the risk of stroke over the subsequent 2 years. However, the perioperative stroke rate is sufficient to nullify any overall benefit of surgery." @default.
- W148594990 created "2016-06-24" @default.
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- W148594990 date "2015-01-01" @default.
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- W148594990 title "Cerebral Oxygen Extraction Fraction in Carotid Occlusive Disease: Measurement and Clinical Significance" @default.
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- W148594990 doi "https://doi.org/10.1016/b978-0-12-397025-1.00095-6" @default.
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