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• W1486028414 abstract "Article1 September 1944DIRECT MEASUREMENTS OF THE EFFECTS OF BROMIDES, SODIUM AMYTAL AND OF CAFFEINE IN MANEDMUND JACOBSON, PH.D., M.D., F.A.C.P.EDMUND JACOBSON, PH.D., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-3-455 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany publications appear each year concerning the influence of stimulants and sedatives in animals and in man. Investigations have afforded much indirect evidence of the action of such agents on the nervous and muscular systems. However, direct quantitative measurements of functional states in the intact organism following the administration of pharmacological substances have never been attempted, doubtless because of lack of suitable instruments. The possibility of such investigation has finally been opened by advances in electrophysiology in the last decade. Most convenient for the present investigation, which I believe marks a first step in this special field, is apparatus capable...Bibliography1. JACOBSON E: (a) The direct measurement of nervous and muscular states with the integrating neurovoltmeter (action-potential integrator), Am. Jr. Psychiat., 1940, xcvii, 513; (b) An integrating voltmeter for the study of nerve and muscle potentials, Rev. Sci. Instr., 1940, xi, 415; (c) Recording action-potentials without photography, Am. Jr. Psychol., 1941, liv, 266. CrossrefGoogle Scholar2. WESTPHAL C: Ueber einige Bewegungs-Erscheinungen an gelähmten Gliedern, Arch. f. Psychiat., 1875, v, 803; ERB, W.: Ueber Sehnenreflexe bei Gesunden und bei Rückenmarkskranken, Arch. f. Psychiat., 1875, v, 792; MITCHELL S. W. LEWIS M. J.: The tendon-jerk and muscle-jerk in disease and especially in posterior sclerosis, Trans. Assoc. Am. Phys., 1886, i, 11; JACOBSON, E., CARLSON A. J.: The influence of relaxation upon the knee-jerk, Am. Jr. Physiol., 1925, lxxiii, 324. CrossrefGoogle Scholar3. JACOBSONKRAFT EFL: Contraction potentials (right quadriceps femoris) in man during reading, Am. Jr. Physiol., 1942, cxxxvii, 1. Google Scholar4. JACOBSON E: Electrical measurements concerning muscular contraction (tonus) and the cultivation of relaxation in man. Studies on arm flexors, Am. Jr. Physiol., 1934, cvii, 230; Electrical measurements concerning muscular contraction (tonus) and the cultivation of relaxation in man. Relaxation-times of individuals, Am. Jr. Physiol., 1934, cviii, 573; The course of relaxation in muscles of athletes, Am. Jr. Psychol., 1936, xlviii, 98; The effect of daily rests without training to relax on muscular tonus, Am. Jr. Psychol., 1942, lv, 248; Tonus in striated muscle, Am. Jr. Psychol., 1943, lvi, 433. Google Scholar5. ADRIANBRONK EDDW: Discharge of impulses in motor nerve fibers; frequency of discharge in reflex and voluntary contractions, Jr. Physiol., 1929, lxvii, 119. Google Scholar6. JACOBSON E: Measurement of the action-potentials in the peripheral nerves of man without anesthetic, Proc. Soc. Exper. Biol. and Med., 1933, xxx, 713. CrossrefGoogle Scholar7. BERGER H: Über das Elektrenkephalogramm des Menschen, Arch. f. Psychiat., 1934, cii, 538; GIBBS F. A. GIBBS E. L. LENNOX W. G.: Effect on the electro-encephalogram of certain drugs which influence nervous activity, Arch. Int. Med., 1937, lx, 154; BERGER, H.: Über das Elektrenkephalogramm des Menschen, Arch. f. Psychiat., 1935, ciii, 452; ANDREWS H. L.: Brain potentials and morphine addiction, Psychosom. Med., 1941, iii, 399; FOWLER O. D.: Neurophysiological and psychological changes induced by certain drugs; electrocortical changes, Jr. Exper. Psychol., 1941, xxviii, 37; LENNOX W. G. GIBBS F. A. GIBBS E. L.: Effect on electro-encephalogram of drugs and conditions which influence seizures, Arch. Neurol. and Psychiat., 1936, xxxvi, 1236. CrossrefGoogle Scholar8. DAVISDAVIS HPA: Action-potentials of brain in normal persons and in normal states of cerebral activity, Arch. Neurol. and Psychiat., 1936, xxxvi, 1214; ANDREWS H. L. JASPER H. H.: Human brain rhythms. I. Recording techniques and preliminary results, Jr. Gen. Psychol., 1936, xiv, 98. CrossrefGoogle Scholar9. ADRIANYAMAGIWA EDK: The origin of the Berger rhythm, Brain, 1935, lviii, 323; HOAGLAND, H.: Pacemakers of human brain waves in normals and in general paretics, Am. Jr. Physiol., 1936, cxvi, 604; HADIDIAN, Z. HOAGLAND H.: Chemical pacemakers for alpha brain wave frequencies in general paresis, Am. Jr. Physiol., 1939, cxxvi, 517; BISHOP G. H.: Abstract of Discussion, Arch. Neurol. and Psychiat., 1936, xxxvi, 1246; SPEIGEL E. A.: Abstract of Discussion, Arch. Neurol. and Psychiat., 1936, xxxvi, 1248. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication October 13, 1943.From the Laboratory for Clinical Physiology, Chicago.Read in abstract before the Section of Pharmacology at the Boston Meeting of The Federation of American Societies for Experimental Biology, April 4, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byElectrophysiology of Mental Activities and Introduction to The Psychological Process of ThinkingCEREBELLAR SYNDROME FOLLOWING SODIUM AMYTAL 1 September 1944Volume 21, Issue 3Page: 455-468KeywordsCaffeineClinical laboratoriesElectrophysiological techniquesNervous systemPharmacologyResearch laboratoriesSedativesSodium ePublished: 1 December 2008 Issue Published: 1 September 1944 PDF downloadLoading ..." @default.
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