FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486100519> ?p ?o ?g. }

• W1486100519 endingPage "80" @default.
• W1486100519 startingPage "876" @default.
• W1486100519 abstract "This study was designed to explore further the relationship between cell proliferation and the induction of early putative preneoplastic lesions by carcinogens. Rats were given a non-necrogenic dose of 1,2-dimethylhydrazine 24 hr before being subjected to partial hepatectomy. Beginning 4 hr later, hydrocortisone was injected 10 times at 4-hr intervals to delay progression through the cell cycle, including inhibition of DNA synthesis by at least 85% for about 40 hr. At the appropriate time thereafter, the putative preneoplastic hepatocytes were selectively stimulated to grow in vivo into gamma-glutamyltransferase-positive focal lesions. Animals given hydrocortisone showed a large decrease (71%) in the number of gamma-glutamyltransferase-positive foci. In contrast, when hydrocortisone was given at 6 days after partial hepatectomy, no inhibition in the induction of hepatic lesions was observed. In the next experiments, rats were treated with 1,2-dimethylhydrazine and were subjected to partial hepatectomy at 12, 24, or 48 hr or 1 week thereafter. A significant number of gamma-glutamyltransferase-positive foci was found when partial hepatectomy was performed at 12 or 24 hr but far fewer were found when the operative partial hepatectomy was delayed to 48 hr or 1 week later. Similarly, in long-term experiments, six of 14 animals developed primary hepatocellular carcinoma 13 months after the time of injection of 1,2-dimethylhydrazine when partial hepatectomy was performed at 12 hr, while none of the animals developed liver cancer when the operation was performed at 48 hr. These results imply that the majority of biochemical lesions induced by 1,2-dimethylhydrazine that are relevant to the induction of liver preneoplasia and neoplasia are short-lived and that their persistence is associated with some cellular activity closely related to the cell cycle." @default.
• W1486100519 created "2016-06-24" @default.
• W1486100519 creator A5002778886 @default.
• W1486100519 creator A5030695740 @default.
• W1486100519 creator A5061961269 @default.
• W1486100519 creator A5069080314 @default.
• W1486100519 date "1982-03-01" @default.
• W1486100519 modified "2023-09-23" @default.
• W1486100519 title "Effects of delays in the cell cycle on the induction of preneoplastic and neoplastic lesions in rat liver by 1,2-dimethylhydrazine." @default.
• W1486100519 cites W124885396 @default.
• W1486100519 cites W1488005560 @default.
• W1486100519 cites W1517710050 @default.
• W1486100519 cites W1519187649 @default.
• W1486100519 cites W1521408862 @default.
• W1486100519 cites W1531211559 @default.
• W1486100519 cites W1558322086 @default.
• W1486100519 cites W1561806477 @default.
• W1486100519 cites W1585780501 @default.
• W1486100519 cites W1598373075 @default.
• W1486100519 cites W1611219263 @default.
• W1486100519 cites W1673447411 @default.
• W1486100519 cites W1935172140 @default.
• W1486100519 cites W1982419990 @default.
• W1486100519 cites W2003396737 @default.
• W1486100519 cites W2014974226 @default.
• W1486100519 cites W2035973152 @default.
• W1486100519 cites W2054659904 @default.
• W1486100519 cites W2064414056 @default.
• W1486100519 cites W2070432039 @default.
• W1486100519 cites W2072891772 @default.
• W1486100519 cites W2115890573 @default.
• W1486100519 cites W2145313252 @default.
• W1486100519 cites W2159634222 @default.
• W1486100519 cites W2285466600 @default.
• W1486100519 cites W2304288424 @default.
• W1486100519 cites W2340676292 @default.
• W1486100519 cites W2397355990 @default.
• W1486100519 cites W2399449767 @default.
• W1486100519 cites W81874192 @default.
• W1486100519 cites W1964025370 @default.
• W1486100519 cites W2607549238 @default.
• W1486100519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7059985" @default.
• W1486100519 hasPublicationYear "1982" @default.
• W1486100519 type Work @default.
• W1486100519 sameAs 1486100519 @default.
• W1486100519 citedByCount "14" @default.
• W1486100519 crossrefType "journal-article" @default.
• W1486100519 hasAuthorship W1486100519A5002778886 @default.
• W1486100519 hasAuthorship W1486100519A5030695740 @default.
• W1486100519 hasAuthorship W1486100519A5061961269 @default.
• W1486100519 hasAuthorship W1486100519A5069080314 @default.
• W1486100519 hasConcept C114246631 @default.
• W1486100519 hasConcept C121608353 @default.
• W1486100519 hasConcept C126322002 @default.
• W1486100519 hasConcept C134018914 @default.
• W1486100519 hasConcept C141071460 @default.
• W1486100519 hasConcept C142724271 @default.
• W1486100519 hasConcept C150903083 @default.
• W1486100519 hasConcept C159110652 @default.
• W1486100519 hasConcept C185592680 @default.
• W1486100519 hasConcept C207001950 @default.
• W1486100519 hasConcept C2776909242 @default.
• W1486100519 hasConcept C2777745080 @default.
• W1486100519 hasConcept C2778709874 @default.
• W1486100519 hasConcept C2779932572 @default.
• W1486100519 hasConcept C526805850 @default.
• W1486100519 hasConcept C55493867 @default.
• W1486100519 hasConcept C71924100 @default.
• W1486100519 hasConcept C86803240 @default.
• W1486100519 hasConcept C90924648 @default.
• W1486100519 hasConceptScore W1486100519C114246631 @default.
• W1486100519 hasConceptScore W1486100519C121608353 @default.
• W1486100519 hasConceptScore W1486100519C126322002 @default.
• W1486100519 hasConceptScore W1486100519C134018914 @default.
• W1486100519 hasConceptScore W1486100519C141071460 @default.
• W1486100519 hasConceptScore W1486100519C142724271 @default.
• W1486100519 hasConceptScore W1486100519C150903083 @default.
• W1486100519 hasConceptScore W1486100519C159110652 @default.
• W1486100519 hasConceptScore W1486100519C185592680 @default.
• W1486100519 hasConceptScore W1486100519C207001950 @default.
• W1486100519 hasConceptScore W1486100519C2776909242 @default.
• W1486100519 hasConceptScore W1486100519C2777745080 @default.
• W1486100519 hasConceptScore W1486100519C2778709874 @default.
• W1486100519 hasConceptScore W1486100519C2779932572 @default.
• W1486100519 hasConceptScore W1486100519C526805850 @default.
• W1486100519 hasConceptScore W1486100519C55493867 @default.
• W1486100519 hasConceptScore W1486100519C71924100 @default.
• W1486100519 hasConceptScore W1486100519C86803240 @default.
• W1486100519 hasConceptScore W1486100519C90924648 @default.
• W1486100519 hasIssue "3" @default.
• W1486100519 hasLocation W14861005191 @default.
• W1486100519 hasOpenAccess W1486100519 @default.
• W1486100519 hasPrimaryLocation W14861005191 @default.
• W1486100519 hasRelatedWork W1486100519 @default.
• W1486100519 hasRelatedWork W1914992772 @default.
• W1486100519 hasRelatedWork W2016514788 @default.
• W1486100519 hasRelatedWork W2046811214 @default.
• W1486100519 hasRelatedWork W2059031176 @default.

• next