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- W1486135698 abstract "Abstract Objective: of relapse in Malaysian patients with obsessive-compulsive disorder. This post-hoc analysis examined the efficacy and tolerability of escitalopram in the prevention Participants and Methods: In Malaysia, 47 patients with obsessive-compulsive disorder were treated with open-label escitalopram (10 mg or 20 mg/day) for 16 weeks, after which the 34 responders (Yale- Brown Obsessive Compulsive Scale total decrease score, ≥ 25%) were randomised to placebo or escitalopram for 24 weeks, using a double-blind protocol. Results: respect to time to relapse (log-rank test, p = 0.07). A higher proportion of patients relapsed after placebo treatment (5 of 14, 36%) than with escitalopram treatment (2 of 20, 10%) [Fisher’s exact test, 2-sided; p = 0.10]. The risk of relapse was 4-fold higher for placebo than escitalopram treatment (p = 0.09). During the double-blind period, the proportion of patients reporting treatment-emergent adverse events was comparable in the 2 groups (10% in the escitalopram group vs. 14% in the placebo group); no serious events being reported. The primary efficacy analysis suggested a trend in favour of escitalopram treatment with Conclusions: This post-hoc subgroup analysis suggests that escitalopram is well tolerated in Malaysian patients with obsessive-compulsive disorder and appears to confer an advantage over placebo, in terms of time to relapse and other efficacy variables. Key words: Citalopram; Obsessive-compulsive disorder; Recurrence; Treatment outcome" @default.
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- W1486135698 date "2008-04-01" @default.
- W1486135698 modified "2023-09-22" @default.
- W1486135698 title "Escitalopram in the treatment of Malaysian patients with Obsessive-compulsive disorder" @default.
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