FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486175985> ?p ?o ?g. }

• W1486175985 abstract "Toxoplasma gondii was first identified more than 100 years ago in the tissues of birds and mammals. In 1908 Nicolle and Manceoux described it for the first time in the gundi (Ctenodactylus gundi), a North African rodent, in tachyzoite forms. At the same time, Splendore in Brazil, identified the parasite in rabbit tissues. Due to its bow-like shape (Greek: Toxo = Arc) the genus was named Toxoplasma. However, only in the 1970’s was the complete life cycle known and the parasite recognized as a coccidian parasite (member of the phylum Apicomplexa). It is ubiquitous throughout the world and estimated to infect approximately half of the world's population. It is characterized by a polarized cell structure and two unique apical secretory organelles called micronemes and rhoptries. Toxoplasma has a complex life cycle consisting of a sexual cycle in its feline definitive hosts and an asexual cycle in its intermediate hosts. The latter, including humans, can be infected by ingestion of oocysts shed in cat feces. Unlike most other Apicomplexan parasites, Toxoplasma can be transmitted between intermediate hosts by either vertical (via placenta) or horizontal (carnivorism) transmission. Toxoplasma parasite is found in intermediate hosts in two interconvertable stages: bradyzoites and tachyzoites. Bradyzoites, a dormant form, are slow-growing, transmissible and encysted. Infections with bradyzoite-containing cysts occur upon ingestion of undercooked meat. The wall of these cysts is digested inside the host stomach and the released bradyzoites, which are resistant to gastric peptidases, subsequently invade the small intestine. There, they convert into tachyzoites, the rapidly growing, disease-causing form that can infect most nucleated cells, replicate inside a parasitophorous vacuole, egress, and then infect neighboring cells. These tachyzoites activate a potent host immune response that eliminates most of the parasites. Some tachyzoites, however, escape destruction and convert back into bradyzoites. In the absence of an adequate immune response, tachyzoites" @default.
• W1486175985 created "2016-06-24" @default.
• W1486175985 creator A5007564652 @default.
• W1486175985 creator A5058770165 @default.
• W1486175985 creator A5070983426 @default.
• W1486175985 date "2012-03-16" @default.
• W1486175985 modified "2023-10-01" @default.
• W1486175985 title "Toxoplasmosis: Advances and Vaccine Perspectives" @default.
• W1486175985 cites W105679305 @default.
• W1486175985 cites W1545910465 @default.
• W1486175985 cites W1553499552 @default.
• W1486175985 cites W1561670665 @default.
• W1486175985 cites W1590568735 @default.
• W1486175985 cites W1602365181 @default.
• W1486175985 cites W1665796496 @default.
• W1486175985 cites W1888830013 @default.
• W1486175985 cites W1958713593 @default.
• W1486175985 cites W1970202670 @default.
• W1486175985 cites W1971308941 @default.
• W1486175985 cites W1973493403 @default.
• W1486175985 cites W1982070009 @default.
• W1486175985 cites W1982939092 @default.
• W1486175985 cites W1988984693 @default.
• W1486175985 cites W1989623941 @default.
• W1486175985 cites W1992753665 @default.
• W1486175985 cites W1996881279 @default.
• W1486175985 cites W1997454452 @default.
• W1486175985 cites W1999409141 @default.
• W1486175985 cites W2000163652 @default.
• W1486175985 cites W2005578116 @default.
• W1486175985 cites W2005958919 @default.
• W1486175985 cites W2006994926 @default.
• W1486175985 cites W2007835398 @default.
• W1486175985 cites W2009630817 @default.
• W1486175985 cites W2011398376 @default.
• W1486175985 cites W2013679658 @default.
• W1486175985 cites W2016544450 @default.
• W1486175985 cites W2019087904 @default.
• W1486175985 cites W2025326880 @default.
• W1486175985 cites W2026271369 @default.
• W1486175985 cites W2026705342 @default.
• W1486175985 cites W2029564173 @default.
• W1486175985 cites W2034191276 @default.
• W1486175985 cites W2035960077 @default.
• W1486175985 cites W2037760095 @default.
• W1486175985 cites W2040564967 @default.
• W1486175985 cites W2043279262 @default.
• W1486175985 cites W2048819202 @default.
• W1486175985 cites W2052925324 @default.
• W1486175985 cites W2053227042 @default.
• W1486175985 cites W2057163795 @default.
• W1486175985 cites W2062646790 @default.
• W1486175985 cites W2071492284 @default.
• W1486175985 cites W2078575618 @default.
• W1486175985 cites W2088209890 @default.
• W1486175985 cites W2090252510 @default.
• W1486175985 cites W2090532607 @default.
• W1486175985 cites W2094949433 @default.
• W1486175985 cites W2097090163 @default.
• W1486175985 cites W2107708892 @default.
• W1486175985 cites W2113703742 @default.
• W1486175985 cites W2116943579 @default.
• W1486175985 cites W2127287184 @default.
• W1486175985 cites W2129841974 @default.
• W1486175985 cites W2131861425 @default.
• W1486175985 cites W2133868033 @default.
• W1486175985 cites W2139798809 @default.
• W1486175985 cites W2144501429 @default.
• W1486175985 cites W2151830950 @default.
• W1486175985 cites W2159768727 @default.
• W1486175985 cites W2161177862 @default.
• W1486175985 cites W2161577035 @default.
• W1486175985 cites W2162555339 @default.
• W1486175985 cites W2163708282 @default.
• W1486175985 cites W2211734948 @default.
• W1486175985 cites W2299862831 @default.
• W1486175985 cites W2313080328 @default.
• W1486175985 cites W2327814076 @default.
• W1486175985 cites W2347251577 @default.
• W1486175985 cites W2381762025 @default.
• W1486175985 doi "https://doi.org/10.5772/26802" @default.
• W1486175985 hasPublicationYear "2012" @default.
• W1486175985 type Work @default.
• W1486175985 sameAs 1486175985 @default.
• W1486175985 citedByCount "1" @default.
• W1486175985 countsByYear W14861759852013 @default.
• W1486175985 crossrefType "book-chapter" @default.
• W1486175985 hasAuthorship W1486175985A5007564652 @default.
• W1486175985 hasAuthorship W1486175985A5058770165 @default.
• W1486175985 hasAuthorship W1486175985A5070983426 @default.
• W1486175985 hasBestOaLocation W14861759851 @default.
• W1486175985 hasConcept C159047783 @default.
• W1486175985 hasConcept C2778062946 @default.
• W1486175985 hasConcept C71924100 @default.
• W1486175985 hasConceptScore W1486175985C159047783 @default.
• W1486175985 hasConceptScore W1486175985C2778062946 @default.
• W1486175985 hasConceptScore W1486175985C71924100 @default.
• W1486175985 hasLocation W14861759851 @default.
• W1486175985 hasLocation W14861759852 @default.
• W1486175985 hasOpenAccess W1486175985 @default.

• next