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• W1486178170 abstract "Several studies published in 2009 suggested that single nucleotide polymorphisms (SNPs) and viral markers in the IL28B gene locus (Ge et al., 2009; Suppiah et al., 2009 and Tanaka et al., 2009) are associated with increased risk of poor response to therapy. IL28B is a member of the interferon (IFN) cytokine family known as IFN III or Lamda (IFN-λ), which includes three types: IFN-λ1 (IL-29), -λ2 (IL-28A) and -λ3 (IL-28B). These are encoded by 3 different genes located on chromosome 19 (Kotenko et al., 2003; Sheppard et al., 2003). rs12979860 genotype (CC, TT, C/T) was the first polymorphism of the IL28B gene to be identified and was associated with a twofold improvement with treatment of HCV infection amongst people of European (P= 1.063 X10ˉ²⁵), Hispanic (P= 4.39 X 10ˉ³) and African-American (P= 2.06 X 10ˉ³) ancestry (Goldstein et al., 2009). Seventy per cent of Caucasians, 40% of African-Americans and 95% of Asians carry at least one copy of the rs12979860C variant allele (Hezode and Chevaliez, 2010). Amongst Egyptians, the CC genotype was significant (p 0.05). The frequency of RS-17 and RS-60 in the UK samples was not significantly correlated with treatment response (P > 0.05). In addition, in the NR, the HBV frequency of RS-17 GT was 25%, TT 66.3% and GG 0%. In patients who achieved SVR, approximately 47% of the genotypes were GT and 100% were GG; no TT genotypes were identified. The PR group showed a higher frequency for TT (33.3%) than GT (25%); no GG genotypes were identified. The RS-17 (P > 0.05 for all) and RS=60 (P > 0.05) genotype frequencies were not significantly correlated with treatment response. In HIV patients, RS-17 and NR were significantly correlated (P= 0.010). The GG genotype was present in 53%, GT in 57.4% and TT in 22.2% of the patients who did not achieve SVR.In the patients who achieved SVR, TT and GG had a similar frequency (26.3%) and GT had a frequency of 20.4%. In the PR group, TT was the most common genotype (37%), followed by GT (18.5%) and GG (10.5%). No significant correlations were observed between RS-17 and either PR or R (P > 0.05). Treatment response and the frequency of IL28B for the RS-60 genotypes were significantly correlated (P= 0.001). Twenty-one per cent of the patients achieved SVR, with the highest frequency having the CT genotype (26%), followed by CC (11.8%). Forty-seven per cent of the HIV patients failed to respond. The CC genotype was the most common (77%), followed by TT (50%) and CT (40%). The relationship between IL28B for the RS60 genotypes and the NR group was statistically significant (P = 0.023). In the PR group, the most common genotype was TT (40%), followed by CT (23.3%) and CC (5.9%). The relationship between the IL28B RS60 genotypes and PR was statistically significant (P = 0.002). The results for the RS-17 genotype in KSA-HIV correlated significantly with viral load (P = 0.034)." @default.
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• W1486178170 date "2012-11-30" @default.
• W1486178170 modified "2023-10-02" @default.
• W1486178170 title "CROSS-SECTIONAL STUDY OF IL28B POLYMORPHISMS AMONGST SAUDI ARABIAN AND BRITISH HCV PATIENTS" @default.
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• W1486178170 cites W2021158901 @default.
• W1486178170 cites W2022057836 @default.
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