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• W1486187546 abstract "Ventricular function has conventionally been characterized using indexes of systolic (contractile) or diastolic (relaxation/stiffness) function. Systolic indexes include maximum elastance or equivalently the end-systolic pressure volume relation and left ventricular ejection fraction. Diastolic indexes include the time constant of isovolumic relaxation - and the end-diastolic pressure-volume relation. Conceptualization of ventricular contraction/relaxation coupling presents a challenge when mechanical events of the cardiac cycle are depicted in conventional pressure, P, or volume, V, terms. Additional conceptual difficulty arises when ventricular/vascular coupling is considered using P, V variables.We introduce the concept of thermodynamic phase-plane, TPP, defined by the PdV and VdP axes.TPP allows all cardiac mechanical events and their coupling to the vasculature to be geometrically depicted and simultaneously analyzed.Conventional systolic and diastolic function indexes are easily recovered and novel indexes of contraction-relaxation coupling are discernible." @default.
• W1486187546 created "2016-06-24" @default.
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• W1486187546 date "2004-03-05" @default.
• W1486187546 modified "2023-09-28" @default.
• W1486187546 title "Thermodynamic phase plane analysis of ventricular contraction and relaxation" @default.
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• W1486187546 doi "https://doi.org/10.1186/1475-925x-3-6" @default.
• W1486187546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/385247" @default.
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