FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486194914> ?p ?o ?g. }

• W1486194914 endingPage "131" @default.
• W1486194914 startingPage "111" @default.
• W1486194914 abstract "Summaryo1.Glutamate is the predominant endogenous EAA at fast-acting synapses in the CNS but also serves an equally important function as an intermediate in carbohydrate and nitrogen metabolism.2.Other endogenous EAAs such as aspartate, cysteine sulphinate, and homocysteate may also function as excitatory transmitters.3.Information transfer between neurons using the EAAs is mediated by at least four subtypes of receptor, namely, the NMDA, AMPA, KA, and metabotropic receptors.4.The NMDA, AMPA, and KA receptor subtypes are directly linked to cation channels, whereas the mGluR is coupled via a G protein to various intracellular second messengers.5.The NMDA receptor exhibits special pharmacological properties consistent with an involvement in higher neural functions.6.Paradoxically, the same properties of the NMDA receptor may be responsible for initiating neuronal cell damage evident in a number of acute and chronic neuropathologies.7.AMPA and KA receptors contribute to the faster excitatory neurotransmission; AMPA receptor activation appears to provide the initial depolarizing stimulus necessary for removing the voltage-block of the NMDA receptor-coupled ion channel.8.The slower-acting mGluRs may serve a modulatory role in neurotransmission. At present, their role in normal and abnormal brain function is uncertain.9.A number of highly potent and selective EAA receptor antagonists have been synthesized; unfortunately, their inability to permeate the blood-brain barrier following systemic administration means that none are currently in clinical use. It is expected, however, that suitable drugs will soon be developed. Glutamate is the predominant endogenous EAA at fast-acting synapses in the CNS but also serves an equally important function as an intermediate in carbohydrate and nitrogen metabolism. Other endogenous EAAs such as aspartate, cysteine sulphinate, and homocysteate may also function as excitatory transmitters. Information transfer between neurons using the EAAs is mediated by at least four subtypes of receptor, namely, the NMDA, AMPA, KA, and metabotropic receptors. The NMDA, AMPA, and KA receptor subtypes are directly linked to cation channels, whereas the mGluR is coupled via a G protein to various intracellular second messengers. The NMDA receptor exhibits special pharmacological properties consistent with an involvement in higher neural functions. Paradoxically, the same properties of the NMDA receptor may be responsible for initiating neuronal cell damage evident in a number of acute and chronic neuropathologies. AMPA and KA receptors contribute to the faster excitatory neurotransmission; AMPA receptor activation appears to provide the initial depolarizing stimulus necessary for removing the voltage-block of the NMDA receptor-coupled ion channel. The slower-acting mGluRs may serve a modulatory role in neurotransmission. At present, their role in normal and abnormal brain function is uncertain. A number of highly potent and selective EAA receptor antagonists have been synthesized; unfortunately, their inability to permeate the blood-brain barrier following systemic administration means that none are currently in clinical use. It is expected, however, that suitable drugs will soon be developed." @default.
• W1486194914 created "2016-06-24" @default.
• W1486194914 creator A5047670474 @default.
• W1486194914 date "1997-01-01" @default.
• W1486194914 modified "2023-10-16" @default.
• W1486194914 title "Chapter 6 Excitatory amino acid receptors" @default.
• W1486194914 cites W1586492351 @default.
• W1486194914 cites W1842711843 @default.
• W1486194914 cites W1965211768 @default.
• W1486194914 cites W1966681799 @default.
• W1486194914 cites W1967113275 @default.
• W1486194914 cites W1981146651 @default.
• W1486194914 cites W1997568797 @default.
• W1486194914 cites W1998347917 @default.
• W1486194914 cites W2004567663 @default.
• W1486194914 cites W2005025211 @default.
• W1486194914 cites W2049511526 @default.
• W1486194914 cites W2057537207 @default.
• W1486194914 cites W2059334396 @default.
• W1486194914 cites W2063461600 @default.
• W1486194914 cites W2066439059 @default.
• W1486194914 cites W2066439205 @default.
• W1486194914 cites W2072465507 @default.
• W1486194914 cites W2081678712 @default.
• W1486194914 cites W2085210285 @default.
• W1486194914 cites W2094975095 @default.
• W1486194914 cites W2170029299 @default.
• W1486194914 cites W2180941170 @default.
• W1486194914 cites W567574166 @default.
• W1486194914 cites W610173514 @default.
• W1486194914 cites W636807714 @default.
• W1486194914 cites W656126208 @default.
• W1486194914 doi "https://doi.org/10.1016/s1569-2582(97)80068-2" @default.
• W1486194914 hasPublicationYear "1997" @default.
• W1486194914 type Work @default.
• W1486194914 sameAs 1486194914 @default.
• W1486194914 citedByCount "0" @default.
• W1486194914 crossrefType "book-chapter" @default.
• W1486194914 hasAuthorship W1486194914A5047670474 @default.
• W1486194914 hasConcept C112592302 @default.
• W1486194914 hasConcept C160268369 @default.
• W1486194914 hasConcept C169760540 @default.
• W1486194914 hasConcept C170493617 @default.
• W1486194914 hasConcept C17077164 @default.
• W1486194914 hasConcept C185592680 @default.
• W1486194914 hasConcept C200170125 @default.
• W1486194914 hasConcept C26702167 @default.
• W1486194914 hasConcept C49051014 @default.
• W1486194914 hasConcept C55493867 @default.
• W1486194914 hasConcept C61174792 @default.
• W1486194914 hasConcept C67018056 @default.
• W1486194914 hasConcept C73009533 @default.
• W1486194914 hasConcept C86803240 @default.
• W1486194914 hasConcept C88272193 @default.
• W1486194914 hasConceptScore W1486194914C112592302 @default.
• W1486194914 hasConceptScore W1486194914C160268369 @default.
• W1486194914 hasConceptScore W1486194914C169760540 @default.
• W1486194914 hasConceptScore W1486194914C170493617 @default.
• W1486194914 hasConceptScore W1486194914C17077164 @default.
• W1486194914 hasConceptScore W1486194914C185592680 @default.
• W1486194914 hasConceptScore W1486194914C200170125 @default.
• W1486194914 hasConceptScore W1486194914C26702167 @default.
• W1486194914 hasConceptScore W1486194914C49051014 @default.
• W1486194914 hasConceptScore W1486194914C55493867 @default.
• W1486194914 hasConceptScore W1486194914C61174792 @default.
• W1486194914 hasConceptScore W1486194914C67018056 @default.
• W1486194914 hasConceptScore W1486194914C73009533 @default.
• W1486194914 hasConceptScore W1486194914C86803240 @default.
• W1486194914 hasConceptScore W1486194914C88272193 @default.
• W1486194914 hasLocation W14861949141 @default.
• W1486194914 hasOpenAccess W1486194914 @default.
• W1486194914 hasPrimaryLocation W14861949141 @default.
• W1486194914 hasRelatedWork W1486194914 @default.
• W1486194914 hasRelatedWork W1999597545 @default.
• W1486194914 hasRelatedWork W2104417933 @default.
• W1486194914 hasRelatedWork W2126134918 @default.
• W1486194914 hasRelatedWork W2132700535 @default.
• W1486194914 hasRelatedWork W2415592649 @default.
• W1486194914 hasRelatedWork W2756235183 @default.
• W1486194914 hasRelatedWork W2802075251 @default.
• W1486194914 hasRelatedWork W3178071059 @default.
• W1486194914 hasRelatedWork W37342803 @default.
• W1486194914 isParatext "false" @default.
• W1486194914 isRetracted "false" @default.
• W1486194914 magId "1486194914" @default.
• W1486194914 workType "book-chapter" @default.