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• W1486208308 startingPage "9430" @default.
• W1486208308 abstract "Spontaneous neuronal activity is essential to neural development. Until recently, neurons were believed to be the only excitable cells to display spontaneous activity. However, cultured astrocytes and, more recently, astrocytes <i>in situ</i> are now known to exhibit spontaneous Ca²⁺ transients. Here we used Ca²⁺ imaging of astrocytes from transgenic mice for the simultaneous monitoring of [Ca²⁺]_ichanges in large numbers of astrocytes. We found that spontaneous activity is a common property of most brain astrocytes that is lost in response to a lesion. These spontaneous [Ca²⁺]_i oscillations require extracellular and intracellular Ca²⁺. Moreover, network analysis revealed that most astrocytes formed correlated networks of dozens of these cells, which were synchronous with both astrocytes and neurons. We found that decreasing spontaneous [Ca²⁺]_i transients in neurons by TTX does not alter the number of active astrocytes, although it impairs their synchronous network activity. Conversely, bicuculline-induced epileptic patterns of [Ca²⁺]_itransients in neurons cause an increase in the number of active astrocytes and in their network synchrony. Furthermore, activation of non-NMDA and NMDA ionotropic glutamate receptors is required to correlate astrocytic networks. These results show that spontaneous activity in astrocytes and neurons is patterned into correlated neuronal/astrocytic networks in which neuronal activity regulates the network properties of astrocytes. This network activity may be essential for neural development and synaptic plasticity." @default.
• W1486208308 created "2016-06-24" @default.
• W1486208308 creator A5021668720 @default.
• W1486208308 creator A5045991293 @default.
• W1486208308 creator A5052138280 @default.
• W1486208308 creator A5058130823 @default.
• W1486208308 date "2002-11-01" @default.
• W1486208308 modified "2023-10-16" @default.
• W1486208308 title "Neuronal Activity Regulates Correlated Network Properties of Spontaneous Calcium Transients in Astrocytes<i>In Situ</i>" @default.
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• W1486208308 doi "https://doi.org/10.1523/jneurosci.22-21-09430.2002" @default.
• W1486208308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6758057" @default.
• W1486208308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12417668" @default.
• W1486208308 hasPublicationYear "2002" @default.
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