FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486223516> ?p ?o ?g. }

• W1486223516 endingPage "263" @default.
• W1486223516 startingPage "257" @default.
• W1486223516 abstract "Patients with Paget's bone disease (PDB) have an increased risk of developing giant cell tumor (GCT). This study was performed to evaluate the clinical characteristics and evolution of GCT complicating PDB and to compare these clinical characteristics to those observed in two large PDB cohorts, the PDB Italian Registry and the United Kingdom's Multi-Centre Randomised Controlled Trial of Symptomatic Versus Intensive Bisphosphonate Therapy for Paget's Disease (PRISM) study. A systematic literature review identified 117 cases of PDB complicated by GCT (PDB-GCT), which involved the skeletal sites affected by PDB (110 patients) or the extraskeletal tissues adjacent to affected bones (7 patients). In contrast to what previously reported for GCT patients without GCT patients (83.2%) were white and one-fourth of them (24.8%) had multifocal GCTs. Compared to PDB patients without GCT, PDB-GCT patients showed a higher male/female ratio (2.1 versus 1.2) and more severe disease (age at PDB onset 52.1 ± 12.1 versus 63.3 ± 10.6 years; number of affected sites 6.1 ± 2.9 versus 2.34 ± 1.6; prevalence of polyostotic PDB 93.3% versus 60.6%). The mortality rate of PDB-GCT patients was higher than those occurring in GCT patients without PDB (about 50% versus 0% to 5% at 5 years) or in PDB patients without GCT (log rank = 29.002). Moreover, up to 98% of PDB-GCT cases had elevated total alkaline phosphatase levels at neoplasm diagnosis, suggestive of active PDB. Importantly, PDB-GCT patients from Southern Italy (45.6% of all GCT patients) showed a higher prevalence of multifocal GCT (51.7%) and of positive familial history for PDB (70.8%) and GCT (65.0%). Finally, indirect evidence suggests a decline in the incidence of GCT in PDB patients. The occurrence of GCT in PDB patients is associated with severe disease and reduced life expectancy of affected patients. The increased prevalence of familial diseases in PDB-GCT patients from Southern Italy suggests a founder effect. The observed changes over time in the incidence of GCT in PDB patients could be related to improved clinical management and/or living conditions of patients." @default.
• W1486223516 created "2016-06-24" @default.
• W1486223516 creator A5013534702 @default.
• W1486223516 creator A5018174118 @default.
• W1486223516 creator A5020528232 @default.
• W1486223516 creator A5026041314 @default.
• W1486223516 creator A5036667571 @default.
• W1486223516 creator A5047654183 @default.
• W1486223516 creator A5048078483 @default.
• W1486223516 creator A5052576992 @default.
• W1486223516 creator A5058278117 @default.
• W1486223516 creator A5091640132 @default.
• W1486223516 date "2015-01-22" @default.
• W1486223516 modified "2023-10-12" @default.
• W1486223516 title "Clinical Characteristics and Evolution of Giant Cell Tumor Occurring in Paget's Disease of Bone" @default.
• W1486223516 cites W1573938644 @default.
• W1486223516 cites W1873398935 @default.
• W1486223516 cites W1965055436 @default.
• W1486223516 cites W1975097503 @default.
• W1486223516 cites W1988940455 @default.
• W1486223516 cites W1991517573 @default.
• W1486223516 cites W2014947424 @default.
• W1486223516 cites W2016084217 @default.
• W1486223516 cites W2016987712 @default.
• W1486223516 cites W2017953817 @default.
• W1486223516 cites W2017981992 @default.
• W1486223516 cites W2024418715 @default.
• W1486223516 cites W2026541346 @default.
• W1486223516 cites W2030772446 @default.
• W1486223516 cites W2036350682 @default.
• W1486223516 cites W2041900270 @default.
• W1486223516 cites W2050028170 @default.
• W1486223516 cites W2070938144 @default.
• W1486223516 cites W2071309974 @default.
• W1486223516 cites W2089800656 @default.
• W1486223516 cites W2093049275 @default.
• W1486223516 cites W2093920652 @default.
• W1486223516 cites W2118523343 @default.
• W1486223516 cites W2149821313 @default.
• W1486223516 cites W2150182323 @default.
• W1486223516 cites W2155769183 @default.
• W1486223516 cites W2164338645 @default.
• W1486223516 cites W2172284214 @default.
• W1486223516 cites W4322695778 @default.
• W1486223516 doi "https://doi.org/10.1002/jbmr.2349" @default.
• W1486223516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25196811" @default.
• W1486223516 hasPublicationYear "2015" @default.
• W1486223516 type Work @default.
• W1486223516 sameAs 1486223516 @default.
• W1486223516 citedByCount "35" @default.
• W1486223516 countsByYear W14862235162015 @default.
• W1486223516 countsByYear W14862235162016 @default.
• W1486223516 countsByYear W14862235162017 @default.
• W1486223516 countsByYear W14862235162018 @default.
• W1486223516 countsByYear W14862235162019 @default.
• W1486223516 countsByYear W14862235162020 @default.
• W1486223516 countsByYear W14862235162021 @default.
• W1486223516 countsByYear W14862235162022 @default.
• W1486223516 countsByYear W14862235162023 @default.
• W1486223516 crossrefType "journal-article" @default.
• W1486223516 hasAuthorship W1486223516A5013534702 @default.
• W1486223516 hasAuthorship W1486223516A5018174118 @default.
• W1486223516 hasAuthorship W1486223516A5020528232 @default.
• W1486223516 hasAuthorship W1486223516A5026041314 @default.
• W1486223516 hasAuthorship W1486223516A5036667571 @default.
• W1486223516 hasAuthorship W1486223516A5047654183 @default.
• W1486223516 hasAuthorship W1486223516A5048078483 @default.
• W1486223516 hasAuthorship W1486223516A5052576992 @default.
• W1486223516 hasAuthorship W1486223516A5058278117 @default.
• W1486223516 hasAuthorship W1486223516A5091640132 @default.
• W1486223516 hasBestOaLocation W14862235161 @default.
• W1486223516 hasConcept C126322002 @default.
• W1486223516 hasConcept C142724271 @default.
• W1486223516 hasConcept C2776154862 @default.
• W1486223516 hasConcept C2779134260 @default.
• W1486223516 hasConcept C55493867 @default.
• W1486223516 hasConcept C65556437 @default.
• W1486223516 hasConcept C71924100 @default.
• W1486223516 hasConcept C86803240 @default.
• W1486223516 hasConceptScore W1486223516C126322002 @default.
• W1486223516 hasConceptScore W1486223516C142724271 @default.
• W1486223516 hasConceptScore W1486223516C2776154862 @default.
• W1486223516 hasConceptScore W1486223516C2779134260 @default.
• W1486223516 hasConceptScore W1486223516C55493867 @default.
• W1486223516 hasConceptScore W1486223516C65556437 @default.
• W1486223516 hasConceptScore W1486223516C71924100 @default.
• W1486223516 hasConceptScore W1486223516C86803240 @default.
• W1486223516 hasIssue "2" @default.
• W1486223516 hasLocation W14862235161 @default.
• W1486223516 hasLocation W14862235162 @default.
• W1486223516 hasLocation W14862235163 @default.
• W1486223516 hasLocation W14862235164 @default.
• W1486223516 hasLocation W14862235165 @default.
• W1486223516 hasOpenAccess W1486223516 @default.
• W1486223516 hasPrimaryLocation W14862235161 @default.
• W1486223516 hasRelatedWork W1486223516 @default.
• W1486223516 hasRelatedWork W2055821700 @default.
• W1486223516 hasRelatedWork W2062806205 @default.

• next