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- W1486249536 abstract "Blocking of cell-mediated lympholysis (CML) by anti-Lyt-2 antibodies was compared with that by anti-H-2 antibodies which most likely inhibit CML by blocking antigen recognition by cytotoxic T lymphocytes (CTLs). Both antibodies were shown to inhibit the early Mg2+-dependent process of killing. Moreover, the anti-H-2-sensitive event was found to be reversible by the antibody as was the case with the anti-Lyt-2-sensitive event, suggesting that the two antibodies block the same event taking place during the Mg2+-dependent stage. Both types of antibody were also shown to be capable of inhibiting the phytohemagglutinin (PHA)-mediated non-specific killing activity of CTLs. However, in the case of anti-Lyt-2 antibodies, available monoclonal antibodies failed to inhibit PHA-mediated killing whereas conventional antisera did. The results thus suggest multiplicity and heterogeneity of Lyt-2 determinants or the existence of multiple products of Lyt-2-linked genes. In addition, an anti-H-2 antiserum also exerted a specific inhibitory effect on PHA-mediated killing. Thus there appears to be a general requirement for involvement of the Lyt-2 molecules on CTLs and major histocompatibility complex (MHC) products on the target cells. The implications of these observations are discussed." @default.
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- W1486249536 date "1983-12-01" @default.
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- W1486249536 title "Mouse Alloantibodies Capable of Blocking Cytotoxic T Cell Function" @default.
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- W1486249536 doi "https://doi.org/10.1111/j.1348-0421.1983.tb02930.x" @default.
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