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• W1486280907 abstract "In 2006, Shinya Yamanaka and colleagues reported that only four transcription factors were needed to reprogram mouse fibroblasts back in development into cells similar to embryonic stem cells (ESCs). These reprogrammed cells were called induced pluripotent stem cells (iPSCs). The year after, iPSCs were successfully produced from human fibroblasts and in 2008 reprogramming cells were chosen as the breakthrough of the year by Science magazine. In particular, this was due to the establishment of patient-specific cell lines from patients with various diseases using the induced pluripotent stem cell (iPSC) technique. IPSCs can be patient specific and therefore may prove useful in several applications, such as; screens for potential drugs, regenerative medicine, models for specific human diseases and in models for patient specific diseases. When using iPSCs in academics, drug development, and industry, it is important to determine whether the derived cells faithfully capture biological processes and relevant disease phenotypes. This chapter provides a summary of cell types of human origin that have been transformed into iPSCs and of different iPSC procedures that exist. Furthermore we discuss advantages and disadvantages of procedures, potential medical applications and implications that may arise in the iPSC field." @default.
• W1486280907 created "2016-06-24" @default.
• W1486280907 creator A5023271122 @default.
• W1486280907 creator A5074789497 @default.
• W1486280907 creator A5078105671 @default.
• W1486280907 date "2012-02-24" @default.
• W1486280907 modified "2023-10-14" @default.
• W1486280907 title "Generation of Patient Specific Stem Cells: A Human Model System" @default.
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