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- W1486303233 abstract "This chapter focuses on the structural features of vesicular acetylcholine transporter (VAChT) deduced from its primary sequence, which give insight into its transporter function, describes the distribution of VAChT in the rat and primate nervous systems and its intracellular targeting to synaptic vesicles in neuronal cells, presents the ontogeny of VAChT and choline acetyltransferase (ChAT) expression in an in vitro model for developing spinal cord motor neurons, and discusses the implications of the phylogenetic conservation of the VAChT/ChAT cholinergic gene locus for the developmental and evolutionary ontogenesis of the cholinergic nervous system. The vesicular acetylcholine transporter, together with ChAT, is a part of a gene locus that is nominally sufficient to confer cholinergic function on a neuronal cell. As such, the VAChT/ChAT gene locus can be looked upon as a cholinergic operon responsible for assembling a metabolic/sequestration pathway in cholinergic cells. The extracellular signals, which is ultimately responsible for the regulation of this operon, may include trophic factors and other neurotransmitters. Recent work suggests that adrenergic neurotransmission, by stimulating production of cholinergic differentiation factor(s) from presumptive cholinergic target tissue, is a decisive stimulus for the development of the cholinergic phenotype in the autonomic nervous system, and cholinergic neurotransmission may be necessary to stabilize the peripheral cholinergic phenotype." @default.
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- W1486303233 date "1996-01-01" @default.
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- W1486303233 title "Chapter 5 The VAChT/ChAT “cholinergic gene locus”: new aspects of genetic and vesicular regulation of cholinergic function" @default.
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- W1486303233 doi "https://doi.org/10.1016/s0079-6123(08)62089-0" @default.
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