FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486333463> ?p ?o ?g. }

• W1486333463 endingPage "765" @default.
• W1486333463 startingPage "761" @default.
• W1486333463 abstract "Chronic granulomatous disease (CGD) comprises a heterogeneous group of inherited conditions characterized biochemically by disordered function of a unique multicomponent enzyme system present in phagocytic cells, the NADPH-oxidase. Clinically, it is characterized by recurrent bacterial and fungal infections that are relatively resistant to treatment by conventional means. Curative bone marrow transplantation has been successfully achieved in a small number of cases, but the wider application of this procedure is limited by availability of suitable donor material. Somatic gene therapy would overcome this problem, and several groups have now shown correction of the biochemical defect in hematopoietic cells by retrovirus-mediated gene transfer. However, the failure of the current generation of retroviral vectors to efficiently transduce quiescent cells greatly restricts their potential for gene transfer to pluripotent hematopoietic stem cells. Given these limitations, we have constructed vectors based on adeno-associated virus and used these to transfer a functional copy of the p47phox gene to immortalized B cells derived from patients with p47phox-deficient autosomal recessive CGD. We show stable expression of protein and restoration of NADPH-oxidase function in these cells in the absence of selection. Adeno-associated virus vectors may overcome some of the limitations of retroviral gene delivery systems and may therefore be a useful vehicle for curative gene therapy of CGD and other primary immunodeficiencies." @default.
• W1486333463 created "2016-06-24" @default.
• W1486333463 creator A5009778023 @default.
• W1486333463 creator A5015147725 @default.
• W1486333463 creator A5015856478 @default.
• W1486333463 creator A5046187430 @default.
• W1486333463 creator A5080562824 @default.
• W1486333463 creator A5080762141 @default.
• W1486333463 creator A5081419098 @default.
• W1486333463 creator A5082895750 @default.
• W1486333463 date "1995-07-15" @default.
• W1486333463 modified "2023-09-30" @default.
• W1486333463 title "Functional reconstitution of the NADPH-oxidase by adeno-associated virus gene transfer" @default.
• W1486333463 cites W1486348543 @default.
• W1486333463 cites W1554330891 @default.
• W1486333463 cites W1583193370 @default.
• W1486333463 cites W1604836384 @default.
• W1486333463 cites W1619719840 @default.
• W1486333463 cites W1777726345 @default.
• W1486333463 cites W1806895515 @default.
• W1486333463 cites W1973287769 @default.
• W1486333463 cites W1999883129 @default.
• W1486333463 cites W2015077972 @default.
• W1486333463 cites W2035183484 @default.
• W1486333463 cites W2038036971 @default.
• W1486333463 cites W2040096357 @default.
• W1486333463 cites W2047711627 @default.
• W1486333463 cites W2076560706 @default.
• W1486333463 cites W2076749094 @default.
• W1486333463 cites W2078458905 @default.
• W1486333463 cites W2084210336 @default.
• W1486333463 cites W2088686424 @default.
• W1486333463 cites W2088851522 @default.
• W1486333463 cites W2090653160 @default.
• W1486333463 cites W2097072158 @default.
• W1486333463 cites W2118944608 @default.
• W1486333463 cites W2121944814 @default.
• W1486333463 cites W2159246453 @default.
• W1486333463 cites W2336648578 @default.
• W1486333463 cites W257878791 @default.
• W1486333463 doi "https://doi.org/10.1182/blood.v86.2.761.bloodjournal862761" @default.
• W1486333463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7606005" @default.
• W1486333463 hasPublicationYear "1995" @default.
• W1486333463 type Work @default.
• W1486333463 sameAs 1486333463 @default.
• W1486333463 citedByCount "17" @default.
• W1486333463 crossrefType "journal-article" @default.
• W1486333463 hasAuthorship W1486333463A5009778023 @default.
• W1486333463 hasAuthorship W1486333463A5015147725 @default.
• W1486333463 hasAuthorship W1486333463A5015856478 @default.
• W1486333463 hasAuthorship W1486333463A5046187430 @default.
• W1486333463 hasAuthorship W1486333463A5080562824 @default.
• W1486333463 hasAuthorship W1486333463A5080762141 @default.
• W1486333463 hasAuthorship W1486333463A5081419098 @default.
• W1486333463 hasAuthorship W1486333463A5082895750 @default.
• W1486333463 hasBestOaLocation W14863334631 @default.
• W1486333463 hasConcept C104317684 @default.
• W1486333463 hasConcept C107459253 @default.
• W1486333463 hasConcept C109159458 @default.
• W1486333463 hasConcept C111599444 @default.
• W1486333463 hasConcept C134305767 @default.
• W1486333463 hasConcept C141071460 @default.
• W1486333463 hasConcept C145103041 @default.
• W1486333463 hasConcept C203014093 @default.
• W1486333463 hasConcept C2522874641 @default.
• W1486333463 hasConcept C2778107364 @default.
• W1486333463 hasConcept C2778175462 @default.
• W1486333463 hasConcept C2778431562 @default.
• W1486333463 hasConcept C2779719074 @default.
• W1486333463 hasConcept C28328180 @default.
• W1486333463 hasConcept C2911091166 @default.
• W1486333463 hasConcept C32470452 @default.
• W1486333463 hasConcept C40767141 @default.
• W1486333463 hasConcept C48349386 @default.
• W1486333463 hasConcept C54009773 @default.
• W1486333463 hasConcept C54355233 @default.
• W1486333463 hasConcept C71924100 @default.
• W1486333463 hasConcept C86803240 @default.
• W1486333463 hasConcept C92087593 @default.
• W1486333463 hasConcept C95444343 @default.
• W1486333463 hasConceptScore W1486333463C104317684 @default.
• W1486333463 hasConceptScore W1486333463C107459253 @default.
• W1486333463 hasConceptScore W1486333463C109159458 @default.
• W1486333463 hasConceptScore W1486333463C111599444 @default.
• W1486333463 hasConceptScore W1486333463C134305767 @default.
• W1486333463 hasConceptScore W1486333463C141071460 @default.
• W1486333463 hasConceptScore W1486333463C145103041 @default.
• W1486333463 hasConceptScore W1486333463C203014093 @default.
• W1486333463 hasConceptScore W1486333463C2522874641 @default.
• W1486333463 hasConceptScore W1486333463C2778107364 @default.
• W1486333463 hasConceptScore W1486333463C2778175462 @default.
• W1486333463 hasConceptScore W1486333463C2778431562 @default.
• W1486333463 hasConceptScore W1486333463C2779719074 @default.
• W1486333463 hasConceptScore W1486333463C28328180 @default.
• W1486333463 hasConceptScore W1486333463C2911091166 @default.
• W1486333463 hasConceptScore W1486333463C32470452 @default.
• W1486333463 hasConceptScore W1486333463C40767141 @default.
• W1486333463 hasConceptScore W1486333463C48349386 @default.

• next