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• W1486343183 abstract "Article1 September 1939THE VITAMIN C REQUIREMENT IN RHEUMATOID ARTHRITISMARSHALL G. HALL, M.D., ROBERT C. DARLING, M.D., F. H. L. TAYLOR, PH.D.MARSHALL G. HALL, M.D.Search for more papers by this author, ROBERT C. DARLING, M.D.Search for more papers by this author, F. H. L. TAYLOR, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-3-415 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn normal healthy individuals the blood serum or plasma level and the urinary excretion of vitamin C are dependent largely upon the dietary intake of the vitamin.1, 2, 3, 4 It has been shown by van Eckelen5 and Heinemann6 that normal adults have a daily requirement of 60 mg. of the vitamin.The presence of infection is known to increase the requirements for vitamin C.7In patients suffering with various forms of infection the level of vitamin C in the blood plasma or serum may be reduced to the level found in patients with scurvy.7Under these circumstances the amount...Bibliography1. ABTFARMEREPSTEIN AFCJIM: Normal cevitamic (ascorbic acid) determinations in blood plasma and their relationship to capillary resistance, Jr. Pediat., 1936, viii, 1. CrossrefGoogle Scholar2. VAN ECKELEN M: On the metabolism of ascorbic acid, Acta brev. Neerland., 1935, v, 165. Google Scholar3. HARRISRAY LJAN: Diagnosis of vitamin C subnutrition by urine analysis with a note on the antiscorbutic value of human milk, Lancet, 1935, i, 71. CrossrefGoogle Scholar4. YOUMANCORLETTEAKEROYDFRANK JBMBJHH: Studies of vitamin C excretion and saturation, Am. Jr. Med. Sci., 1936, cxci, 319. CrossrefGoogle Scholar5. VAN ECKELEN M: On the amount of ascorbic acid in the blood and urine. The daily human requirements for ascorbic acid, Biochem. Jr., 1936, xxx, 1119. Google Scholar6. HEINEMANN MI: On the relation between diet and urinary output of thiosulphate and ascorbic acid, Biochem. Jr., 1936, xxx, 2291. Google Scholar7. FAULKNERTAYLOR JMFH: Vitamin C and infection, ANN. INT. MED., 1937, x, 1867. LinkGoogle Scholar8. FAULKNERTAYLOR JMFH: Observations on the renal threshold for ascorbic acid in man, Jr. Clin. Invest., 1938, xviii, 69. CrossrefGoogle Scholar9. RINEHARTGREENBERGBAKER JFLDF: Reduced ascorbic acid content of blood plasma in rheumatoid arthritis, Proc. Soc. Exper. Biol. and Med., 1936, xxxv, 347. CrossrefGoogle Scholar10. RINEHARTGREENBERGCHRISTIE JFLDAU: Reduced ascorbic acid content of blood plasma in rheumatic fever, Proc. Soc. Exper. Biol. and Med., 1936, xxxv, 350. CrossrefGoogle Scholar11. FARMERABT CJAF: Determination of reduced ascorbic acid in small amounts of blood, Proc. Soc. Exper. Biol. and Med., 1936, xxxiv, 146. CrossrefGoogle Scholar12. TAYLORCHASEFAULKNER FHDJM: Estimation of reduced ascorbic acid in blood serum and plasma, Biochem. Jr., 1936, xxx, 1119. CrossrefGoogle Scholar13. WRIGHTLILIENFELD ISA: Pharmacologic and therapeutic properties of crystalline vitamin C (cevitamic acid). With special reference to its effects on the capillary fragility, Arch. Int. Med., 1936, lvii, 241. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication June 29, 1938.From the Medical Service of the Robert B. Brigham Hospital; the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard) of the Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNutrition and Rheumatic DiseasesNutritional Modulation of Autoimmune DiseasesDIETS, DIETARY SUPPLEMENTS, AND NUTRITIONAL THERAPIES IN RHEUMATIC DISEASESInadequate calcium, folic acid, vitamin E, zinc, and selenium intake in rheumatoid arthritis patients: results of a dietary surveyDoes Food Cause or Cure Arthritis?The effects of postharvest treatment and chemical interactions on the bioavailability of ascorbic acid, thiamin, vitamin a, carotenoids, and mineralsNutritional status and growth in juvenile rheumatoid arthritisClinical biochemical measurements in rheumatologyAre rheumatoid arthritis and systemic lupus erythematosus inversely related diseases?The Determination of Dehydroascorbic Acid and Ascorbic acid in the Serum and Synovial Fluid of Patients with Rheumatoid Arthritis (RA)The Interactions of Aspirin and Ascorbic Acid In Normal MenThe Effects of Aspirin on the Metabolic Availability of Ascorbic Acid in Human BeingsDie Pathologie der Avitaminosen und HypervitaminosenAetiology and pathogenesis of rheumatoid arthritisPhysiology of the Adrenal CortexThe Physiology and Biochemistry of Ascorbic AcidVitamin B Excretion Studies in Patients with Rheumatoid ArthritisThe Modern Treatment of Rheumatoid ArthritisThe Use of Vitamins in the Treatment of Chronic ArthritisThe Blood in Arthritis 1 September 1939Volume 13, Issue 3Page: 415-423KeywordsBlood plasmaExcretionHospital medicineMedical servicesResearch laboratoriesRheumatoid arthritisVitamin C ePublished: 1 December 2008 Issue Published: 1 September 1939 PDF downloadLoading ..." @default.
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