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- W148636098 abstract "This chapter discusses the biosynthesis of nucleic acids. Much of the basic work on the de novo formation of purines was done with birds, which are good experimental animals, as they excrete nitrogen as uric acid. Hartman and Buchanan (1958a) purified 5-phosphoribosylpyrophosphate amidotransferase (ribosylamine-5-phosphate: pyrophosphate phosphoribosyltransferase [glutamate-amidating]) from extracts of pigeon liver. This enzyme catalyzes the first reaction of purine biosynthesis, the formation of 5-phosphoribosylamine from 5-phosphoribosylpyrophosphate and glutamine. Buchanan and Hartman (1959) suggested that this reaction resulted in inversion of the configuration at carbon 1 of ribose as purine ribosides are of the β configuration while 5-phosphoribosylpyrophosphate has the configuration Merlich and Magasanik (1965a) partially purified the enzyme from A. aerogenes and showed that low concentrations of purine ribonucleotides inhibited the action of the enzyme. This result was expected as it is currently a common observation that the first enzyme of a biosynthetic pathway is subject to end-product inhibition. Hartman and Buchanan (1958b) also purified the second enzyme of the purine biosynthetic pathway, glycineamide ribonucleotide synthetase (ribosylamine-5-phosphate: glycine ligase [ADP]), and established that it catalyzed the condensation of glycine and 5-phosphoribosylamine to form glycinamide ribonucleotide. ATP was utilized in the reaction and served as a source of chemical energy for the formation of the amide linkage." @default.
- W148636098 created "2016-06-24" @default.
- W148636098 creator A5062333613 @default.
- W148636098 date "1969-01-01" @default.
- W148636098 modified "2023-10-16" @default.
- W148636098 title "BIOSYNTHESIS OF NUCLEIC ACIDS" @default.
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