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- W1486365785 abstract "Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger signals. The subsequent cascade of enzymatic reactions is tightly regulated to assure that complement is activated only at specific locations requiring defense against pathogens, thus avoiding host tissue damage. Here we discuss the recent advances describing the molecular and structural basis of activation and regulation of the complement pathways and their implication on physiology and pathology. This article will review the mechanisms of activation of alternative, classical and lectin pathways, the formation of C3 and C5 convertases, the action of anaphylatoxins and the membrane attack complex. We will also discuss the importance of structure-function relationships using the example of atypical hemolytic uremic syndrome. Lastly we will discuss the development and benefits of therapies using complement inhibitors." @default.
- W1486365785 created "2016-06-24" @default.
- W1486365785 creator A5025683973 @default.
- W1486365785 creator A5040351599 @default.
- W1486365785 creator A5041083432 @default.
- W1486365785 creator A5051276814 @default.
- W1486365785 date "2015-06-02" @default.
- W1486365785 modified "2023-10-18" @default.
- W1486365785 title "Complement System Part I – Molecular Mechanisms of Activation and Regulation" @default.
- W1486365785 cites W10173812 @default.
- W1486365785 cites W102699897 @default.
- W1486365785 cites W1209169208 @default.
- W1486365785 cites W121687570 @default.
- W1486365785 cites W1247518833 @default.
- W1486365785 cites W1481229608 @default.
- W1486365785 cites W1485186526 @default.
- W1486365785 cites W1487925140 @default.
- W1486365785 cites W1499593166 @default.
- W1486365785 cites W1502672079 @default.
- W1486365785 cites W1502774063 @default.
- W1486365785 cites W1502806342 @default.
- W1486365785 cites W1507314459 @default.
- W1486365785 cites W1517172525 @default.
- W1486365785 cites W1517507077 @default.
- W1486365785 cites W1529745308 @default.
- W1486365785 cites W1541628337 @default.
- W1486365785 cites W1550517269 @default.
- W1486365785 cites W1552704337 @default.
- W1486365785 cites W1553763534 @default.
- W1486365785 cites W1555889999 @default.
- W1486365785 cites W1559536687 @default.
- W1486365785 cites W1563729327 @default.
- W1486365785 cites W1570116363 @default.
- W1486365785 cites W1586044007 @default.
- W1486365785 cites W1589826140 @default.
- W1486365785 cites W1590773547 @default.
- W1486365785 cites W1602285939 @default.
- W1486365785 cites W1604121414 @default.
- W1486365785 cites W1606415249 @default.
- W1486365785 cites W1611849651 @default.
- W1486365785 cites W1614793601 @default.
- W1486365785 cites W1630187190 @default.
- W1486365785 cites W1659710835 @default.
- W1486365785 cites W1673834499 @default.
- W1486365785 cites W169718174 @default.
- W1486365785 cites W1707478454 @default.
- W1486365785 cites W1751327912 @default.
- W1486365785 cites W1785589283 @default.
- W1486365785 cites W1790999934 @default.
- W1486365785 cites W1824411023 @default.
- W1486365785 cites W1826628219 @default.
- W1486365785 cites W1828340002 @default.
- W1486365785 cites W1833364259 @default.
- W1486365785 cites W1901858952 @default.
- W1486365785 cites W1916830525 @default.
- W1486365785 cites W1941186790 @default.
- W1486365785 cites W1954296697 @default.
- W1486365785 cites W1963203481 @default.
- W1486365785 cites W1963618204 @default.
- W1486365785 cites W1965855950 @default.
- W1486365785 cites W1965972308 @default.
- W1486365785 cites W1969193157 @default.
- W1486365785 cites W1969797382 @default.
- W1486365785 cites W1970232820 @default.
- W1486365785 cites W1971296511 @default.
- W1486365785 cites W1971422062 @default.
- W1486365785 cites W1971594322 @default.
- W1486365785 cites W1971767825 @default.
- W1486365785 cites W1971908086 @default.
- W1486365785 cites W1972001423 @default.
- W1486365785 cites W1972084384 @default.
- W1486365785 cites W1972398559 @default.
- W1486365785 cites W1973289394 @default.
- W1486365785 cites W1973410879 @default.
- W1486365785 cites W1973530374 @default.
- W1486365785 cites W1974183132 @default.
- W1486365785 cites W1974210499 @default.
- W1486365785 cites W1975460168 @default.
- W1486365785 cites W1975807362 @default.
- W1486365785 cites W1976736415 @default.
- W1486365785 cites W1977446721 @default.
- W1486365785 cites W1978958492 @default.
- W1486365785 cites W1979351627 @default.
- W1486365785 cites W1979443248 @default.
- W1486365785 cites W1979551570 @default.
- W1486365785 cites W1979923548 @default.
- W1486365785 cites W1980273151 @default.
- W1486365785 cites W1981124925 @default.
- W1486365785 cites W1981535135 @default.
- W1486365785 cites W1982816312 @default.
- W1486365785 cites W1983115827 @default.
- W1486365785 cites W1983556802 @default.
- W1486365785 cites W1983653396 @default.
- W1486365785 cites W1984433766 @default.
- W1486365785 cites W1984887661 @default.
- W1486365785 cites W1985960971 @default.
- W1486365785 cites W1986251054 @default.
- W1486365785 cites W1986592145 @default.
- W1486365785 cites W1987036950 @default.
- W1486365785 cites W1987723450 @default.