FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486372353> ?p ?o ?g. }

• W1486372353 endingPage "14177" @default.
• W1486372353 startingPage "14168" @default.
• W1486372353 abstract "Evidence suggests that the C-terminal truncation of α-synuclein is equally important as aggregation of α-synuclein in Parkinson disease (PD). Our previous results showed that an endopeptidase, matrix metalloproteinase-3 (MMP3), was induced and activated in dopaminergic (DA) cells upon stress conditions. Here, we report that MMP3 cleaved α-synuclein in vitro and in vivo and that α-synuclein and MMP3 were co-localized in Lewy bodies (LB) in the postmortem brains of PD patients. Incubation of α-synuclein with the catalytic domain of MMP3 (cMMP3) resulted in generation of several peptides, and the peptide profiles of WT α-synuclein (WTsyn) and A53T mutant (A53Tsyn) were different. Combined analysis using mass spectrometry and N-terminal determination revealed that MMP3 generated C-terminally truncated peptides of amino acids 1-78, 1-91, and 1-93 and that A53Tsyn produced significantly higher quantities of these peptides. Similar sizes of peptides were detected in N27 DA cells under oxidative stress and RNA interference to knock down MMP3-attenuated peptide generation. Co-overexpression of cMMP3 with either WTsyn or A53Tsyn led to a reduction in Triton X-100-insoluble aggregates and an increase in protofibril-like small aggregates. In addition, overexpression of the 1-93-amino acid peptide in the substantia nigra led to DA neuronal loss without LB-like aggregate formation. The results strongly indicate that MMP3 digestion of α-synuclein in DA neurons plays a pivotal role in the progression of PD through modulation of α-synuclein in aggregation, LB formation, and neurotoxicity." @default.
• W1486372353 created "2016-06-24" @default.
• W1486372353 creator A5005497825 @default.
• W1486372353 creator A5022010111 @default.
• W1486372353 creator A5040633232 @default.
• W1486372353 creator A5046381867 @default.
• W1486372353 creator A5073004789 @default.
• W1486372353 creator A5077421037 @default.
• W1486372353 date "2011-04-01" @default.
• W1486372353 modified "2023-10-12" @default.
• W1486372353 title "Role of Matrix Metalloproteinase 3-mediated α-Synuclein Cleavage in Dopaminergic Cell Death" @default.
• W1486372353 cites W1485468448 @default.
• W1486372353 cites W1504584187 @default.
• W1486372353 cites W1527671059 @default.
• W1486372353 cites W1601052838 @default.
• W1486372353 cites W1807475000 @default.
• W1486372353 cites W1965778124 @default.
• W1486372353 cites W1968957266 @default.
• W1486372353 cites W1979527613 @default.
• W1486372353 cites W1986628169 @default.
• W1486372353 cites W1988463041 @default.
• W1486372353 cites W1989522802 @default.
• W1486372353 cites W1989734945 @default.
• W1486372353 cites W1999014597 @default.
• W1486372353 cites W2008748100 @default.
• W1486372353 cites W2011332000 @default.
• W1486372353 cites W2016628803 @default.
• W1486372353 cites W2018631912 @default.
• W1486372353 cites W2021155980 @default.
• W1486372353 cites W2035787181 @default.
• W1486372353 cites W2042553854 @default.
• W1486372353 cites W2048383114 @default.
• W1486372353 cites W2048721771 @default.
• W1486372353 cites W2073793348 @default.
• W1486372353 cites W2075997185 @default.
• W1486372353 cites W2076798789 @default.
• W1486372353 cites W2077743093 @default.
• W1486372353 cites W2081100775 @default.
• W1486372353 cites W2082283179 @default.
• W1486372353 cites W2084910880 @default.
• W1486372353 cites W2089386161 @default.
• W1486372353 cites W2091265794 @default.
• W1486372353 cites W2106200048 @default.
• W1486372353 cites W2123431154 @default.
• W1486372353 cites W2123869107 @default.
• W1486372353 cites W2127443571 @default.
• W1486372353 cites W2146706912 @default.
• W1486372353 cites W2146950789 @default.
• W1486372353 cites W2150656456 @default.
• W1486372353 cites W2154737306 @default.
• W1486372353 cites W2166789153 @default.
• W1486372353 cites W2240648904 @default.
• W1486372353 cites W4246230178 @default.
• W1486372353 doi "https://doi.org/10.1074/jbc.m111.222430" @default.
• W1486372353 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3077618" @default.
• W1486372353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21330369" @default.
• W1486372353 hasPublicationYear "2011" @default.
• W1486372353 type Work @default.
• W1486372353 sameAs 1486372353 @default.
• W1486372353 citedByCount "96" @default.
• W1486372353 countsByYear W14863723532012 @default.
• W1486372353 countsByYear W14863723532013 @default.
• W1486372353 countsByYear W14863723532014 @default.
• W1486372353 countsByYear W14863723532015 @default.
• W1486372353 countsByYear W14863723532016 @default.
• W1486372353 countsByYear W14863723532017 @default.
• W1486372353 countsByYear W14863723532018 @default.
• W1486372353 countsByYear W14863723532019 @default.
• W1486372353 countsByYear W14863723532020 @default.
• W1486372353 countsByYear W14863723532021 @default.
• W1486372353 countsByYear W14863723532022 @default.
• W1486372353 countsByYear W14863723532023 @default.
• W1486372353 crossrefType "journal-article" @default.
• W1486372353 hasAuthorship W1486372353A5005497825 @default.
• W1486372353 hasAuthorship W1486372353A5022010111 @default.
• W1486372353 hasAuthorship W1486372353A5040633232 @default.
• W1486372353 hasAuthorship W1486372353A5046381867 @default.
• W1486372353 hasAuthorship W1486372353A5073004789 @default.
• W1486372353 hasAuthorship W1486372353A5077421037 @default.
• W1486372353 hasBestOaLocation W14863723531 @default.
• W1486372353 hasConcept C104317684 @default.
• W1486372353 hasConcept C134018914 @default.
• W1486372353 hasConcept C137183658 @default.
• W1486372353 hasConcept C150194340 @default.
• W1486372353 hasConcept C153911025 @default.
• W1486372353 hasConcept C185592680 @default.
• W1486372353 hasConcept C2779281246 @default.
• W1486372353 hasConcept C2779295440 @default.
• W1486372353 hasConcept C2780938664 @default.
• W1486372353 hasConcept C513476851 @default.
• W1486372353 hasConcept C55493867 @default.
• W1486372353 hasConcept C86803240 @default.
• W1486372353 hasConcept C95444343 @default.
• W1486372353 hasConceptScore W1486372353C104317684 @default.
• W1486372353 hasConceptScore W1486372353C134018914 @default.
• W1486372353 hasConceptScore W1486372353C137183658 @default.
• W1486372353 hasConceptScore W1486372353C150194340 @default.
• W1486372353 hasConceptScore W1486372353C153911025 @default.

• next