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- W148640992 abstract "The pharmacokinetics of oxytctracycline, which was given as a single intravenous dose (5 mg/kg), was studied in normal beagle dogs. Renal function was evaluated by the single injection technique and based on clearance of the radioiodine compounds 125I-iothalamate and 131I-iodohippurate. Values of GFR (4.42±0.77 ml/kg/min) and ERPF (12.91±1.49 ml/kg/min) showed normal renal function. The disposition curve describing decline of oxytctracycline activity in serum was described mathematically by a triexponential expression. Body clearance was 4.23±1.29 ml/kg/min. A dosage regimen (intravenous route of drug administration), based on overall elimination rate constant (0.1155 h−1) and apparent specific volume of distribution (2 litre/kg), and consisting of a priming dose (10 mg/kg) followed by maintenance doses (7.5 mg/kg) at 12 h intervals was proposed. This dosage regimen was predicted to rapidly achieve and maintain steady state serum concentrations within the range 1.25 to 5.0 μg/ml, which is therapeutic level for the majority of susceptible microorganisms." @default.
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- W148640992 date "1978-01-01" @default.
- W148640992 modified "2023-09-28" @default.
- W148640992 title "Pharmacokinetics and dosage of oxytetracycline in dogs" @default.
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- W148640992 doi "https://doi.org/10.1016/s0034-5288(18)33102-3" @default.
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