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• W1486450090 endingPage "181" @default.
• W1486450090 startingPage "133" @default.
• W1486450090 abstract "Publisher Summary This chapter concentrates on two discrete aspects of PA and its production by PLDs: (1) The physical and chemical properties of PA in connection with a possible role in specific and nonspecific regulation of enzyme function and (2) novel enzymes involved in PA production that could augment PA production by members of the well-documented HKD-PLD superfamily (so named for a characteristic sequence motif). As part of the characterization of non-HKD-PLDs, enzymes structurally and possibly functionally related to at least one of the non-HKD PLDs, which from Streptomyces chromofuscus, are discussed. It would not come as a surprise if some of these enzymes, or similar ones yet to be described, should turn out to be involved in the control of PA concentration and in signaling. Any intracellular enzyme capable of generating PA from phospholipids could play a role in signal transduction pathways. The only non-HKD enzyme thus far that is known to contribute to signaling is autotaxin, which generates LPA from LPC. It is a secreted protein and exhibits specificity for lyso-PC. Clearly, more biochemical and structural information on the role of metal ions in this enzyme is needed to see if it falls in a similar metalloenzyme class as scPLD and similar phosphodiesterases. The only known mammalian PLD that is a confirmed metalloprotein is GPI-PLD. However, the GPI-PLD appears to play a role in membrane remodeling when it is inside cells. When secreted, its activity is reduced significantly, making activity toward GPI-linked proteins problematic. NAPE-PLD, another potential metallo-PLD, works on a very specific product that is produced at very low concentrations. While action of these latter two PLDs does generate PA, the amounts are unlikely to contribute to basal PA levels in cell membranes." @default.
• W1486450090 created "2016-06-24" @default.
• W1486450090 creator A5047196423 @default.
• W1486450090 creator A5088159774 @default.
• W1486450090 date "2005-01-01" @default.
• W1486450090 modified "2023-10-16" @default.
• W1486450090 title "Non-HKD Phospholipase D Enzymes: New Players in Phosphatidic Acid Signaling?" @default.
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