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- W1486549433 abstract "Abstract Increasing levels of urea increase the fluorescence intensity of bovine growth hormone at neutral pH and shift the pH zone of the transition that occurs in acid to higher pH values. Maxima in the fluorescence intensity curves occur above 3.6 m urea and are displaced to higher pH values at higher urea concentrations. Fluorescence polarization of the conjugate of the hormone with 1-dimethylaminonaphthalene-5-sulfonyl chloride undergoes a complicated series of changes as a function of urea concentration and pH. The pK value of the dimethylamino group of the 1-dimethylaminonaphthalene-5-sulfonyl conjugate of bovine growth hormone is abnormally low in aqueous solution and is gradually normalized by urea. From studies of these phenomena, and of ultraviolet difference spectra of the hormone in urea solutions, five new molecular conformations of bovine growth hormone are inferred. Even the most disorganized conformation, which is found in 9 m urea below pH 5, still appears to retain some organized structure. The helical regions of the bovine growth hormone molecule appear to remain largely intact, even in conformations that differ markedly from that of the native molecule." @default.
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- W1486549433 date "1966-01-01" @default.
- W1486549433 modified "2023-10-03" @default.
- W1486549433 title "The Properties of Bovine Growth Hormone" @default.
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- W1486549433 doi "https://doi.org/10.1016/s0021-9258(18)96939-5" @default.
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