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- W148655461 abstract "The structures of euphopubescenol and euphopubescene, two new macrocyclic jatrophane diterpene polyesters, isolated from the whole dried plant of Euphorbia pubescens, were established as 5α,8α,15β-triacetoxy-3α-benzoyloxy-4α-hydroxy-9,14-dioxo-13βH-jatropha-6(17),11E-diene (1) and 3β,7β,8β,9α,14α,15β-hexaacetoxy-2βH-jatropha-5E,11E-diene (2) by 1D- and 2D-NMR (COSY, HMQC, HMBC and NOESY), IR, EI-MS and EI-FTICR-MS. Two known lathyrane derivatives, jolkinol A (3) and jolkinol A (4), whose 13C-NMR spectra were assigned, were also isolated. Compounds 1 - 3 have been evaluated for their ability to inhibit the in vitro growth of three human tumour cell lines representing different tumour types, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer). They inhibited both MCF-7 and NCI-H460 cell lines, with GI50 values ranging between 40.9 μM and 95.3 μM, but were found to be ineffective as growth inhibitors of the SF-268 cell line." @default.
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- W148655461 date "2004-03-01" @default.
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- W148655461 title "Euphopubescenol and Euphopubescene, Two New Jatrophane Polyesters, and Lathyrane-type Diterpenes from<i>Euphorbia pubescens</i>" @default.
- W148655461 doi "https://doi.org/10.1055/s-2004-815542" @default.
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