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- W1486554974 abstract "This chapter reviews the methods to assess the biological activity of chemokines with focuses on assays using human cells. It outlines the generally preferred methods for each cell type. The assay widely used to characterize the activity of chemokines is the mobilization of intracellular calcium. All chemotactic factors described on all cell types have been shown to elevate the level of intracellular free calcium ion. Normally cells are loaded with a vital dye that acquires new or altered fluorescent properties after interaction with free calcium. Intracellular free calcium is held at a low level in most cells by maintaining a calcium gradient through the action of ion pumps in the plasma membrane, by sequestration into intracellular compartments known as calciosomes, and by the association of intracellular calcium with cell membranes. Often chemokine activation can also be manifest by a change in the expression of a surface marker or by enhanced adhesion. These events are not associated with new protein synthesis but with the activation of integrins or the mobilization of intracellular stores of receptors to the cell surface." @default.
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- W1486554974 date "1997-01-01" @default.
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- W1486554974 title "Biological responses to C-C chemokines" @default.
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- W1486554974 doi "https://doi.org/10.1016/s0076-6879(97)87014-0" @default.
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