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- W1486602114 abstract "A mutant of yeast sensitive to growth inhibition by 2,6-diaminopurine (2,6-DAP) was analyzed genetically and found to be a double mutant. One gene, dap , conferred approximately 30% sensitivity to the analogue. The other, slw , potentiated the inhibition such that the double mutant dap slw was inhibited 90%. The mutation dap conferred concomitant sensitivity to a number of other purine analogues. The activity of a purine phosphoribosyltransferase with 2,6-DAP in a strain carrying dap was found to be three times higher than in the wild type. It is inferred that the mutation alters the properties of a purine phosphoribosyltransferase. A possible mechanism for the effect of slw is also discussed." @default.
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- W1486602114 date "1969-11-01" @default.
- W1486602114 modified "2023-09-23" @default.
- W1486602114 title "Mutant of Yeast Sensitive to 2,6-Diaminopurine" @default.
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- W1486602114 doi "https://doi.org/10.1128/jb.100.2.817-822.1969" @default.
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