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• W1486603669 endingPage "54" @default.
• W1486603669 startingPage "54" @default.
• W1486603669 abstract "SUMMARY OF THESIS* DEGUTI, Marta Mitiko – Esteato-hepatite nao alcoolica: avalia cao clinica, laboratorial, histopatol ogica e pesquisa de muta coes do gene HFE.Casuistica de um Centro de Refer encia. Sao Paulo, 2000. (Disserta cao de Mestrado – Faculdade de Medicina da Universidade de S ao Paulo). NON-ALCOHOLIC STEATOHEPATITIS: CLINICAL, LABORATORY, HISTOPATHOLOGIC EVALUATIONAND SEARCH FOR MUTATIONS IN THE HFE GENE. CASUISTIC FROM A REFERENCE CENTER Non-alcoholic steatohepatitis (NASH) consists of steatosis and hepaticlobular inflammation in non-alcoholic individuals. It occurs in associationto obesity, hyperlipidemia, diabetes mellitus, female sex, drug therapyand jejunoileal bypass. Recently, iron overload, secondary to mutations inthe HFE gene in hereditary hemochromatosis has also been evidenced innon-obese, non-diabetic male patients with NASH. This study involvespatients with NASH from the outpatient clinic of Hospital das Cl inicas ofthe University of Sao Paulo School of Medicine, and its objective was todefine patients ´clinical, laboratory and histological profiles and search formutations in the HFE gene, compare results for associations and reviewthe literature. Thirty-two individuals were characterized for 14 clinicalfeatures, 12 laboratory parameters and 11 histopathological variables. TheC282Y and H63D mutations in 31 of these individuals were searchedusing PCR-RFLP techniques, using restriction enzymes SnaB I and Bcl I,respectively. Age varied from 32 to 76 yrs old, with an average of 49.2yrs. Female Sex (59%), obesity (50%), hyperlipidemia (53%) and diabetesmellitus (31%) had a lower incidence than those in the first series in theliterature. Other features observed were amiodarone and prednisone use,inhalation of industrial chemical substances and extensive enterectomy.Its incidence was higher among Caucasians (72%) and Asians (12%) thanthe general population, contrary to other ethnic types such as Black (absent)and Mulattos (12%) which presented lower incidences. Perivenular fibrosiswas present in all cases, proportional to the degree of necroinflammatoryactivity. Mallory ´s hyalines were identified in 78% of the cases, but hepaticsiderosis was identified in only 9%. Around two-thirds of the casuistic didnot have abdominal complaints. Among the hepatic enzymes, ALT wasthe most frequently altered with the highest magnitudes and the AST/ALT ratio was <2 in all cases. The incidence of the mutations studied wassimilar to those found in the general population. The iron overload inperipheral blood was neither statistically correlated to the histologicalaggression, nor to the presence of mutations. NASH diagnosis dependson multiple features, but in the population studied, there was no associationwith hepatic iron overload as well as with the known mutations in theHFE gene." @default.
• W1486603669 created "2016-06-24" @default.
• W1486603669 creator A5000362894 @default.
• W1486603669 date "2001-02-01" @default.
• W1486603669 modified "2023-09-25" @default.
• W1486603669 title "Non-alcoholic steatohepatitis: clinical, laboratory, histopathologic evaluation and search for mutations in the HFE gene. Casuistic from a reference center" @default.
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• W1486603669 doi "https://doi.org/10.1590/s0036-46652001000100014" @default.
• W1486603669 hasPublicationYear "2001" @default.
• W1486603669 type Work @default.

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