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- W1486634087 abstract "This chapter discusses various antipsychotic and anti-anxiety agents. Most of the compounds discussed in the chapter are tested by two general methods: (1) the study of animal behavior following drug treatment in experimental models designed to mimic a clinical situation (conflict, avoidance, etc.) and (2) the measurement of classical pharmacological reactions caused or modified by the agent under test (anticonvulsant, antiemetic, etc.). The production of catalepsy and the antagonism of the emetic effect of apomorphine are relied upon for predicting the clinical response of anti-psychotic compounds. It has been observed that anti-anxiety agents increase exploratory behavior in inexperienced rats, whereas antipsychotic compounds reduce such activity. It is widely accepted that the antipsychotic drugs function through some interference with adrenergic processes in the brain. Reserpine, for example, is known to deplete the stores of catecholamines in the brain, whereas chlorpromazine has a central adrenolytic action. Although the antipsychotic agents interfere with the brain amines, the causal relationship between the changes and the behavioral effects is less clear. If the brain amines are conceded to play a crucial part in the functioning of the central nervous system, some disorder in the supply, action, or disposal of these agents might be responsible for abnormal behavior." @default.
- W1486634087 created "2016-06-24" @default.
- W1486634087 creator A5028621900 @default.
- W1486634087 date "1966-01-01" @default.
- W1486634087 modified "2023-09-25" @default.
- W1486634087 title "Chapter 1. Antipsychotic and Anti-anxiety Agents" @default.
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