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- W1486646636 abstract "Abstract Preprotachykinin-A (PPT-A) gene products substance P and neurokinin-A have been shown to play an important role in neurogenic inflammation. To investigate the role of PPT-A gene products in lung injury in sepsis, polymicrobial sepsis was induced by cecal ligation and puncture in PPT-A gene-deficient mice (PPT-A−/−) and the wild-type control mice (PPT-A+/+). PPT-A gene deletion significantly protected against mortality, delayed the onset of lethality, and improved the long-term survival following cecal ligation and puncture-induced sepsis. PPT-A−/− mice also had significantly attenuated inflammation and damage in the lungs. The data suggest that deletion of the PPT-A gene may have contributed to the disruption in recruitment of inflammatory cells resulting in protection against tissue damage, as in these mice the sepsis-associated increase in chemokine levels is significantly attenuated." @default.
- W1486646636 created "2016-06-24" @default.
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- W1486646636 date "2006-03-15" @default.
- W1486646636 modified "2023-09-27" @default.
- W1486646636 title "Preprotachykinin-A Gene Products Are Key Mediators of Lung Injury in Polymicrobial Sepsis" @default.
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- W1486646636 doi "https://doi.org/10.4049/jimmunol.176.6.3813" @default.
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