FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486654905> ?p ?o ?g. }

• W1486654905 endingPage "IN15" @default.
• W1486654905 startingPage "817" @default.
• W1486654905 abstract "Neuroblastoma (NB) is the most commonly occurring solid tumor in children. The disease usually arises in the adrenal medulla, and it is characterized by a remarkable heterogeneity in its progression. Most NB patients with an advanced disease have massive bone marrow infiltration at diagnosis. Lung metastasis represents a widely disseminated stage and is typically considered to be a terminal event. Much like other malignancies, NB progression is a complex, multistep process. The expression, function, and significance of the various factors involved in NB progression must be studied in relevant in vivo and in vitro models. Currently, models consisting of metastatic and nonmetastatic cell variants of the same genetic background exist for several types of cancer; however, none exists for NB. In the present study, we describe the generation of a NB metastasis model. SH-SY5Y and MHH-NB-11 NB cells were inoculated orthotopically into the adrenal glands of athymic nude mice. Neuroblastoma cells metastasizing to the lungs were isolated from mice bearing adrenal tumors. Lung metastatic variants were generated by repeated cycles of in vivo passage. Characterization of these variants included cellular morphology and immunophenotyping in vitro, aggressiveness in vivo, and various biologic parameters in vitro. The NB metastatic variant in each model displayed unique properties, and both metastatic variants demonstrated a metastatic phenotype in vivo. These reproducible models of human NB metastasis will serve as an unlimited source of transcriptomic and proteomic material. Such models can facilitate future studies on NB metastasis and the identification of novel NB biomarkers and targets for therapy." @default.
• W1486654905 created "2016-06-24" @default.
• W1486654905 creator A5008818504 @default.
• W1486654905 creator A5027919413 @default.
• W1486654905 creator A5029858514 @default.
• W1486654905 creator A5040920402 @default.
• W1486654905 creator A5045996087 @default.
• W1486654905 creator A5050863624 @default.
• W1486654905 creator A5051618572 @default.
• W1486654905 creator A5063973599 @default.
• W1486654905 creator A5072126409 @default.
• W1486654905 creator A5077523305 @default.
• W1486654905 creator A5086862795 @default.
• W1486654905 date "2008-08-01" @default.
• W1486654905 modified "2023-10-05" @default.
• W1486654905 title "Generation and Characterization of Novel Local and Metastatic Human Neuroblastoma Variants" @default.
• W1486654905 cites W122518273 @default.
• W1486654905 cites W1506397040 @default.
• W1486654905 cites W1520425169 @default.
• W1486654905 cites W1545825939 @default.
• W1486654905 cites W1547913407 @default.
• W1486654905 cites W1970378385 @default.
• W1486654905 cites W1976261697 @default.
• W1486654905 cites W1978591675 @default.
• W1486654905 cites W1987638110 @default.
• W1486654905 cites W1992885568 @default.
• W1486654905 cites W1995837249 @default.
• W1486654905 cites W1999067880 @default.
• W1486654905 cites W2008440424 @default.
• W1486654905 cites W2010750077 @default.
• W1486654905 cites W2011340985 @default.
• W1486654905 cites W2022437509 @default.
• W1486654905 cites W2023554081 @default.
• W1486654905 cites W2023657798 @default.
• W1486654905 cites W2032600439 @default.
• W1486654905 cites W2044074021 @default.
• W1486654905 cites W2067365629 @default.
• W1486654905 cites W2067606868 @default.
• W1486654905 cites W2073006928 @default.
• W1486654905 cites W2077838776 @default.
• W1486654905 cites W2077934554 @default.
• W1486654905 cites W2078012606 @default.
• W1486654905 cites W2082833890 @default.
• W1486654905 cites W2085786448 @default.
• W1486654905 cites W2090985686 @default.
• W1486654905 cites W2093921289 @default.
• W1486654905 cites W2109325347 @default.
• W1486654905 cites W2122053636 @default.
• W1486654905 cites W2138412834 @default.
• W1486654905 cites W2146449631 @default.
• W1486654905 cites W2157187711 @default.
• W1486654905 cites W2165742628 @default.
• W1486654905 doi "https://doi.org/10.1593/neo.08402" @default.
• W1486654905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2504768" @default.
• W1486654905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18683320" @default.
• W1486654905 hasPublicationYear "2008" @default.
• W1486654905 type Work @default.
• W1486654905 sameAs 1486654905 @default.
• W1486654905 citedByCount "23" @default.
• W1486654905 countsByYear W14866549052012 @default.
• W1486654905 countsByYear W14866549052013 @default.
• W1486654905 countsByYear W14866549052014 @default.
• W1486654905 countsByYear W14866549052015 @default.
• W1486654905 countsByYear W14866549052016 @default.
• W1486654905 countsByYear W14866549052017 @default.
• W1486654905 countsByYear W14866549052022 @default.
• W1486654905 crossrefType "journal-article" @default.
• W1486654905 hasAuthorship W1486654905A5008818504 @default.
• W1486654905 hasAuthorship W1486654905A5027919413 @default.
• W1486654905 hasAuthorship W1486654905A5029858514 @default.
• W1486654905 hasAuthorship W1486654905A5040920402 @default.
• W1486654905 hasAuthorship W1486654905A5045996087 @default.
• W1486654905 hasAuthorship W1486654905A5050863624 @default.
• W1486654905 hasAuthorship W1486654905A5051618572 @default.
• W1486654905 hasAuthorship W1486654905A5063973599 @default.
• W1486654905 hasAuthorship W1486654905A5072126409 @default.
• W1486654905 hasAuthorship W1486654905A5077523305 @default.
• W1486654905 hasAuthorship W1486654905A5086862795 @default.
• W1486654905 hasBestOaLocation W14866549051 @default.
• W1486654905 hasConcept C104317684 @default.
• W1486654905 hasConcept C121608353 @default.
• W1486654905 hasConcept C126322002 @default.
• W1486654905 hasConcept C142724271 @default.
• W1486654905 hasConcept C150194340 @default.
• W1486654905 hasConcept C150903083 @default.
• W1486654905 hasConcept C162317418 @default.
• W1486654905 hasConcept C196166836 @default.
• W1486654905 hasConcept C203014093 @default.
• W1486654905 hasConcept C207001950 @default.
• W1486654905 hasConcept C2776715637 @default.
• W1486654905 hasConcept C2779013556 @default.
• W1486654905 hasConcept C2780007613 @default.
• W1486654905 hasConcept C502942594 @default.
• W1486654905 hasConcept C54355233 @default.
• W1486654905 hasConcept C553184892 @default.
• W1486654905 hasConcept C55493867 @default.
• W1486654905 hasConcept C71924100 @default.
• W1486654905 hasConcept C81885089 @default.

• next