FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486704333> ?p ?o ?g. }

• W1486704333 abstract "Abstract Background Compartmental analysis is a standard method to quantify metabolic processes using fluorodeoxyglucose-positron emission tomography (FDG-PET). For liver studies, this analysis is complex due to the hepatocyte capability to dephosphorylate and release glucose and FDG into the blood. Moreover, a tracer is supplied to the liver by both the hepatic artery and the portal vein, which is not visible in PET images. This study developed an innovative computational approach accounting for the reversible nature of FDG in the liver and directly computing the portal vein tracer concentration by means of gut radioactivity measurements. Methods Twenty-one mice were subdivided into three groups: the control group ‘CTR’ ( n = 7) received no treatment, the short-term starvation group ‘STS’ ( n = 7) was submitted to food deprivation with free access to water within 48 h before imaging, and the metformin group ‘MTF’ ( n = 7) was treated with metformin (750 mg/Kg per day) for 1 month. All mice underwent a dynamic micro-PET study for 50 min after an 18 F-FDG injection. The compartmental analysis considered two FDG pools (phosphorylated and free) in both the gut and liver. A tracer was carried into the liver by the hepatic artery and the portal vein, and tracer delivery from the gut was considered as the sole input for portal vein tracer concentration. Accordingly, both the liver and gut were characterized by two compartments and two exchange coefficients. Each one of the two two-compartment models was mathematically described by a system of differential equations, and data optimization was performed by applying a Newton algorithm to the inverse problems associated to these differential systems. Results All rate constants were stable in each group. The tracer coefficient from the free to the metabolized compartment in the liver was increased by STS, while it was unaltered by MTF. By contrast, the tracer coefficient from the metabolized to the free compartment was reduced by MTF and increased by STS. Conclusions Data demonstrated that our method was able to analyze FDG kinetics under pharmacological or pathophysiological stimulation, quantifying the fraction of the tracer trapped in the liver or dephosphorylated and released into the bloodstream." @default.
• W1486704333 created "2016-06-24" @default.
• W1486704333 creator A5007539864 @default.
• W1486704333 creator A5008837796 @default.
• W1486704333 creator A5016534075 @default.
• W1486704333 creator A5024225840 @default.
• W1486704333 creator A5031842403 @default.
• W1486704333 creator A5054482647 @default.
• W1486704333 creator A5069546253 @default.
• W1486704333 creator A5074721259 @default.
• W1486704333 creator A5079274267 @default.
• W1486704333 creator A5088453867 @default.
• W1486704333 date "2015-06-11" @default.
• W1486704333 modified "2023-10-16" @default.
• W1486704333 title "A new compartmental method for the analysis of liver FDG kinetics in small animal models" @default.
• W1486704333 cites W1534954081 @default.
• W1486704333 cites W1986435499 @default.
• W1486704333 cites W2011735982 @default.
• W1486704333 cites W2019509271 @default.
• W1486704333 cites W2035143394 @default.
• W1486704333 cites W2047015463 @default.
• W1486704333 cites W2072095671 @default.
• W1486704333 cites W2090306035 @default.
• W1486704333 cites W2090573979 @default.
• W1486704333 cites W2094880837 @default.
• W1486704333 cites W2097892020 @default.
• W1486704333 cites W2098440711 @default.
• W1486704333 cites W2107153252 @default.
• W1486704333 cites W2107945436 @default.
• W1486704333 cites W2109641816 @default.
• W1486704333 cites W2116727306 @default.
• W1486704333 cites W2121402967 @default.
• W1486704333 cites W2122315101 @default.
• W1486704333 cites W2140613764 @default.
• W1486704333 cites W2146118393 @default.
• W1486704333 cites W2146184955 @default.
• W1486704333 cites W2147917643 @default.
• W1486704333 cites W2152788151 @default.
• W1486704333 cites W2165869744 @default.
• W1486704333 cites W2286499419 @default.
• W1486704333 cites W4293775970 @default.
• W1486704333 cites W2120053582 @default.
• W1486704333 doi "https://doi.org/10.1186/s13550-015-0107-1" @default.
• W1486704333 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4469683" @default.
• W1486704333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26077542" @default.
• W1486704333 hasPublicationYear "2015" @default.
• W1486704333 type Work @default.
• W1486704333 sameAs 1486704333 @default.
• W1486704333 citedByCount "19" @default.
• W1486704333 countsByYear W14867043332016 @default.
• W1486704333 countsByYear W14867043332017 @default.
• W1486704333 countsByYear W14867043332018 @default.
• W1486704333 countsByYear W14867043332019 @default.
• W1486704333 countsByYear W14867043332020 @default.
• W1486704333 countsByYear W14867043332021 @default.
• W1486704333 countsByYear W14867043332023 @default.
• W1486704333 crossrefType "journal-article" @default.
• W1486704333 hasAuthorship W1486704333A5007539864 @default.
• W1486704333 hasAuthorship W1486704333A5008837796 @default.
• W1486704333 hasAuthorship W1486704333A5016534075 @default.
• W1486704333 hasAuthorship W1486704333A5024225840 @default.
• W1486704333 hasAuthorship W1486704333A5031842403 @default.
• W1486704333 hasAuthorship W1486704333A5054482647 @default.
• W1486704333 hasAuthorship W1486704333A5069546253 @default.
• W1486704333 hasAuthorship W1486704333A5074721259 @default.
• W1486704333 hasAuthorship W1486704333A5079274267 @default.
• W1486704333 hasAuthorship W1486704333A5088453867 @default.
• W1486704333 hasBestOaLocation W14867043331 @default.
• W1486704333 hasConcept C121332964 @default.
• W1486704333 hasConcept C126322002 @default.
• W1486704333 hasConcept C185544564 @default.
• W1486704333 hasConcept C2775842073 @default.
• W1486704333 hasConcept C2776820930 @default.
• W1486704333 hasConcept C2777202286 @default.
• W1486704333 hasConcept C2777415128 @default.
• W1486704333 hasConcept C2778863792 @default.
• W1486704333 hasConcept C2779033008 @default.
• W1486704333 hasConcept C2779415379 @default.
• W1486704333 hasConcept C2989005 @default.
• W1486704333 hasConcept C71924100 @default.
• W1486704333 hasConceptScore W1486704333C121332964 @default.
• W1486704333 hasConceptScore W1486704333C126322002 @default.
• W1486704333 hasConceptScore W1486704333C185544564 @default.
• W1486704333 hasConceptScore W1486704333C2775842073 @default.
• W1486704333 hasConceptScore W1486704333C2776820930 @default.
• W1486704333 hasConceptScore W1486704333C2777202286 @default.
• W1486704333 hasConceptScore W1486704333C2777415128 @default.
• W1486704333 hasConceptScore W1486704333C2778863792 @default.
• W1486704333 hasConceptScore W1486704333C2779033008 @default.
• W1486704333 hasConceptScore W1486704333C2779415379 @default.
• W1486704333 hasConceptScore W1486704333C2989005 @default.
• W1486704333 hasConceptScore W1486704333C71924100 @default.
• W1486704333 hasIssue "1" @default.
• W1486704333 hasLocation W14867043331 @default.
• W1486704333 hasLocation W14867043332 @default.
• W1486704333 hasLocation W14867043333 @default.
• W1486704333 hasLocation W14867043334 @default.
• W1486704333 hasOpenAccess W1486704333 @default.
• W1486704333 hasPrimaryLocation W14867043331 @default.
• W1486704333 hasRelatedWork W1515310766 @default.

• next