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• W1486720096 abstract "The contribution of antigen‐driven B‐cell adaptive immune responses within the inflamed muscle of inflammatory myopathies (IMs) is largely unknown. In this study, we investigated the immunoglobulin V H gene repertoire, somatic hypermutation, clonal diversification, and selection of infiltrating B cells in muscle biopsies from IM patients (dermatomyositis and polymyositis), to determine whether B cells and/or plasma cells contribute to the associated pathologies of these diseases. The data reveal that Ig V H gene repertoires of muscle‐infiltrating B cells deviate from the normal V H gene repertoire in individual patients, and differ between different types of IMs. Analysis of somatic mutations revealed clonal diversification of muscle‐infiltrating B cells and evidence for a chronic B‐cell response within the inflamed muscle. We conclude that muscle‐infiltrating B cells undergo selection, somatic hypermutation and clonal diversification in situ during antigen‐driven immune responses in patients with IMs, providing insight into the contribution of B cells to the pathological mechanisms of these disorders." @default.
• W1486720096 created "2016-06-24" @default.
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• W1486720096 date "2014-01-16" @default.
• W1486720096 modified "2023-10-18" @default.
• W1486720096 title "The V_H repertoire and clonal diversification of B cells in inflammatory myopathies" @default.
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• W1486720096 doi "https://doi.org/10.1002/eji.201343315" @default.
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