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• W1486784744 abstract "ABSTRACT Oocyte fertilization rate progressively decreases with the increase of the interval time from the ovulation. This phenomenon follows and parallels the gradual dispersion of the cumulus expanded mass surrounding the ovulated oocytes. Mouse COCs, expanded in vitro with FSH in the presence of serum, undergo to dissociation similarly to in vivo gonadotropin-stimulated COCs. Metabolic labelling of the newly synthesized hyaluronan in this culture condition has allowed determining that this process depends on matrix disassembly and hyaluronan release. In the present paper we provide evidence that an increasing number of cumulus cells undergo to apoptosis after expansion and that hyaluronan release from the matrix closely correlates with this process. In addition, we show that when apoptosis is experimentally prevented, matrix is preserved and the fertilizability of the enclosed oocyte is prolonged." @default.
• W1486784744 created "2016-06-24" @default.
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• W1486784744 date "2002-01-01" @default.
• W1486784744 modified "2023-09-24" @default.
• W1486784744 title "APOPTOSIS AND HYALURONAN-ENRICHED EXTRACELLULAR MATRIX DEGRADATION IN CUMULUS CELL-OOCYTE COMPLEX: IMPLICATION IN FERTILITY" @default.
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• W1486784744 doi "https://doi.org/10.1533/9781845693121.489" @default.
• W1486784744 hasPublicationYear "2002" @default.
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