Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486785068> ?p ?o ?g. }
- W1486785068 endingPage "1115" @default.
- W1486785068 startingPage "1087" @default.
- W1486785068 abstract "Cell proliferation is regulated through a transition between the G0 phase and cell cycle. We isolated a mammalian temperature-sensitive mutant cell line defective in the function from the G0 phase to cell cycle. Senescent human somatic cells fail to enter into the cell cycle from the G0 phase with stimulation by any growth factor. Telomere shortening was found to be a cause of cellular senescence, and reexpression of telomerase immortalized human somatic cells. Immortalized human somatic cells showed normal phenotypes and were useful not only for basic research but also for clinical and applied fields. The importance of p53 and p21 activation/induction i now well accepted in the signal transduction process from telomere shortening to growth arrest, but the precise mechanism is largely unknown as yet. We found that the MAP kinase cascade and histone acetylase have an important role in the signaling process to express p21. Tumor tissues and cells were found to have strong telomerase activity, while most normal somatic human tissues showed very weak or no activity. Telomerase activity was shown to be a good marker for early tumor diagnosis because significant telomerase activity was detected in very early tumors or even in some precancerous tissues compared with adjacent normal tissues. Telomere/telomerase is a candidate target for cancer chemotherapeutics, and an agent that abrogated telomere functions was found to kill tumor cells effectively by inducing apoptosis whereas it showed no effect on the viability of normal cells." @default.
- W1486785068 created "2016-06-24" @default.
- W1486785068 creator A5013776416 @default.
- W1486785068 date "2006-11-01" @default.
- W1486785068 modified "2023-09-23" @default.
- W1486785068 title "Mechanism of Cell Proliferation—Cell Cycle, Oncogenes, and Senescence" @default.
- W1486785068 cites W124198045 @default.
- W1486785068 cites W1505072532 @default.
- W1486785068 cites W1505490601 @default.
- W1486785068 cites W1550920050 @default.
- W1486785068 cites W1931795746 @default.
- W1486785068 cites W1967932820 @default.
- W1486785068 cites W1968110954 @default.
- W1486785068 cites W1968909759 @default.
- W1486785068 cites W1971297568 @default.
- W1486785068 cites W1974331672 @default.
- W1486785068 cites W1974758267 @default.
- W1486785068 cites W1975562645 @default.
- W1486785068 cites W1976334693 @default.
- W1486785068 cites W1980823933 @default.
- W1486785068 cites W1980873868 @default.
- W1486785068 cites W1981711243 @default.
- W1486785068 cites W1983514165 @default.
- W1486785068 cites W1985212888 @default.
- W1486785068 cites W1987459898 @default.
- W1486785068 cites W1989300604 @default.
- W1486785068 cites W1990460343 @default.
- W1486785068 cites W1991346853 @default.
- W1486785068 cites W1992031156 @default.
- W1486785068 cites W1992733063 @default.
- W1486785068 cites W1994910379 @default.
- W1486785068 cites W1996191037 @default.
- W1486785068 cites W1996200002 @default.
- W1486785068 cites W1996593524 @default.
- W1486785068 cites W1997598243 @default.
- W1486785068 cites W1997961060 @default.
- W1486785068 cites W2000140041 @default.
- W1486785068 cites W2000838048 @default.
- W1486785068 cites W2002470174 @default.
- W1486785068 cites W2004314923 @default.
- W1486785068 cites W2013059054 @default.
- W1486785068 cites W2014537110 @default.
- W1486785068 cites W2015172768 @default.
- W1486785068 cites W2015199191 @default.
- W1486785068 cites W2015373078 @default.
- W1486785068 cites W2016306516 @default.
- W1486785068 cites W2017248263 @default.
- W1486785068 cites W2020219744 @default.
- W1486785068 cites W2025047823 @default.
- W1486785068 cites W2027841008 @default.
- W1486785068 cites W2028876859 @default.
- W1486785068 cites W2030136675 @default.
- W1486785068 cites W2034993149 @default.
- W1486785068 cites W2036632168 @default.
- W1486785068 cites W2039955382 @default.
- W1486785068 cites W2043910995 @default.
- W1486785068 cites W2044147556 @default.
- W1486785068 cites W2045424747 @default.
- W1486785068 cites W2046269635 @default.
- W1486785068 cites W2047041586 @default.
- W1486785068 cites W2048250490 @default.
- W1486785068 cites W2048652103 @default.
- W1486785068 cites W2049131789 @default.
- W1486785068 cites W2051956247 @default.
- W1486785068 cites W2053298598 @default.
- W1486785068 cites W2055436445 @default.
- W1486785068 cites W2057201995 @default.
- W1486785068 cites W2057493575 @default.
- W1486785068 cites W2060329343 @default.
- W1486785068 cites W2062507002 @default.
- W1486785068 cites W2063148408 @default.
- W1486785068 cites W2063868707 @default.
- W1486785068 cites W2066591425 @default.
- W1486785068 cites W2067694663 @default.
- W1486785068 cites W2068388010 @default.
- W1486785068 cites W2069373333 @default.
- W1486785068 cites W2070580563 @default.
- W1486785068 cites W2075242951 @default.
- W1486785068 cites W2078220509 @default.
- W1486785068 cites W2081925029 @default.
- W1486785068 cites W2082653439 @default.
- W1486785068 cites W2085160228 @default.
- W1486785068 cites W2085786821 @default.
- W1486785068 cites W2091327298 @default.
- W1486785068 cites W2091960536 @default.
- W1486785068 cites W2093486112 @default.
- W1486785068 cites W2115858886 @default.
- W1486785068 cites W2129695638 @default.
- W1486785068 cites W2130388017 @default.
- W1486785068 cites W2145859123 @default.
- W1486785068 cites W2147226937 @default.
- W1486785068 cites W2148335564 @default.
- W1486785068 cites W2333225812 @default.
- W1486785068 cites W2527135025 @default.
- W1486785068 cites W4234460872 @default.
- W1486785068 cites W4235963509 @default.
- W1486785068 cites W4246976223 @default.
- W1486785068 cites W4253918032 @default.