FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486818238> ?p ?o ?g. }

• W1486818238 endingPage "878" @default.
• W1486818238 startingPage "872" @default.
• W1486818238 abstract "Background and purpose: Results from several studies point to voltage‐gated Na + channels as potential mediators of the immobility produced by inhaled anaesthetics. We hypothesized that the intrathecal administration of tetrodotoxin, a drug that blocks Na + channels, should enhance anaesthetic potency, and that concurrent administration of veratridine, a drug that augments Na + channel opening, should reverse the increase in potency. Experimental approach: We measured the change in isoflurane potency for reducing movement in response to a painful stimulus as defined by MAC (minimum alveolar concentration of anaesthetic required to abolish movement in 50% of subjects) caused by intrathecal infusion of various concentrations of tetrodotoxin into the lumbothoracic subarachnoid space of rats, and the change in MAC caused by the administration of a fixed dose of tetrodotoxin plus various doses of intrathecal veratridine. Key results: Intrathecal infusion of tetrodotoxin (0.078–0.63 µM) produced a reversible dose‐related decrease in MAC, of more than 50% at the highest concentration. Intrathecal co‐administration of veratridine (1.6–6.4 µM) reversed this decrease in a dose‐related manner, with nearly complete reversal at the highest veratridine dose tested. Conclusions and implications: Intrathecal administration of tetrodotoxin increases isoflurane potency (decreases isoflurane MAC), and intrathecal administration of veratridine counteracts this effect in vivo . These findings are consistent with a role for voltage‐gated Na + channel blockade in the immobility produced by inhaled anaesthetics." @default.
• W1486818238 created "2016-06-24" @default.
• W1486818238 creator A5000284406 @default.
• W1486818238 creator A5006880359 @default.
• W1486818238 creator A5017583102 @default.
• W1486818238 creator A5044675573 @default.
• W1486818238 creator A5056426328 @default.
• W1486818238 creator A5073012775 @default.
• W1486818238 creator A5082855062 @default.
• W1486818238 date "2010-02-01" @default.
• W1486818238 modified "2023-10-06" @default.
• W1486818238 title "Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats" @default.
• W1486818238 cites W1968530210 @default.
• W1486818238 cites W1969621131 @default.
• W1486818238 cites W1984048538 @default.
• W1486818238 cites W1988782252 @default.
• W1486818238 cites W2001196949 @default.
• W1486818238 cites W2001508159 @default.
• W1486818238 cites W2002066071 @default.
• W1486818238 cites W2004727131 @default.
• W1486818238 cites W2013464874 @default.
• W1486818238 cites W2017183797 @default.
• W1486818238 cites W2023444285 @default.
• W1486818238 cites W2034954698 @default.
• W1486818238 cites W2039795325 @default.
• W1486818238 cites W2040725197 @default.
• W1486818238 cites W2055241837 @default.
• W1486818238 cites W2055345952 @default.
• W1486818238 cites W2057227458 @default.
• W1486818238 cites W2059131440 @default.
• W1486818238 cites W2060262374 @default.
• W1486818238 cites W2061695857 @default.
• W1486818238 cites W2063636594 @default.
• W1486818238 cites W2066835774 @default.
• W1486818238 cites W2067326992 @default.
• W1486818238 cites W2075365473 @default.
• W1486818238 cites W2076251265 @default.
• W1486818238 cites W2077437334 @default.
• W1486818238 cites W2092963962 @default.
• W1486818238 cites W2101261772 @default.
• W1486818238 cites W2101986800 @default.
• W1486818238 cites W2105954846 @default.
• W1486818238 cites W2110571052 @default.
• W1486818238 cites W2130972481 @default.
• W1486818238 cites W2145822280 @default.
• W1486818238 cites W2156798177 @default.
• W1486818238 cites W2160645050 @default.
• W1486818238 cites W2169478814 @default.
• W1486818238 doi "https://doi.org/10.1111/j.1476-5381.2009.00583.x" @default.
• W1486818238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2829212" @default.
• W1486818238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20105175" @default.
• W1486818238 hasPublicationYear "2010" @default.
• W1486818238 type Work @default.
• W1486818238 sameAs 1486818238 @default.
• W1486818238 citedByCount "17" @default.
• W1486818238 countsByYear W14868182382012 @default.
• W1486818238 countsByYear W14868182382013 @default.
• W1486818238 countsByYear W14868182382014 @default.
• W1486818238 countsByYear W14868182382015 @default.
• W1486818238 countsByYear W14868182382016 @default.
• W1486818238 countsByYear W14868182382017 @default.
• W1486818238 countsByYear W14868182382019 @default.
• W1486818238 countsByYear W14868182382022 @default.
• W1486818238 countsByYear W14868182382023 @default.
• W1486818238 crossrefType "journal-article" @default.
• W1486818238 hasAuthorship W1486818238A5000284406 @default.
• W1486818238 hasAuthorship W1486818238A5006880359 @default.
• W1486818238 hasAuthorship W1486818238A5017583102 @default.
• W1486818238 hasAuthorship W1486818238A5044675573 @default.
• W1486818238 hasAuthorship W1486818238A5056426328 @default.
• W1486818238 hasAuthorship W1486818238A5073012775 @default.
• W1486818238 hasAuthorship W1486818238A5082855062 @default.
• W1486818238 hasBestOaLocation W14868182382 @default.
• W1486818238 hasConcept C134018914 @default.
• W1486818238 hasConcept C178790620 @default.
• W1486818238 hasConcept C185592680 @default.
• W1486818238 hasConcept C202751555 @default.
• W1486818238 hasConcept C2776359302 @default.
• W1486818238 hasConcept C2776414672 @default.
• W1486818238 hasConcept C2776741303 @default.
• W1486818238 hasConcept C2776986425 @default.
• W1486818238 hasConcept C42219234 @default.
• W1486818238 hasConcept C50952357 @default.
• W1486818238 hasConcept C537181965 @default.
• W1486818238 hasConcept C55493867 @default.
• W1486818238 hasConcept C57992300 @default.
• W1486818238 hasConcept C71924100 @default.
• W1486818238 hasConcept C98274493 @default.
• W1486818238 hasConceptScore W1486818238C134018914 @default.
• W1486818238 hasConceptScore W1486818238C178790620 @default.
• W1486818238 hasConceptScore W1486818238C185592680 @default.
• W1486818238 hasConceptScore W1486818238C202751555 @default.
• W1486818238 hasConceptScore W1486818238C2776359302 @default.
• W1486818238 hasConceptScore W1486818238C2776414672 @default.
• W1486818238 hasConceptScore W1486818238C2776741303 @default.
• W1486818238 hasConceptScore W1486818238C2776986425 @default.
• W1486818238 hasConceptScore W1486818238C42219234 @default.
• W1486818238 hasConceptScore W1486818238C50952357 @default.

• next