Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486844399> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1486844399 endingPage "291" @default.
- W1486844399 startingPage "283" @default.
- W1486844399 abstract "We have characterized the mechanisms by which thrombin enhances neutrophil leukocyte (PMN) adhesion to human endothelial cells in vitro. Thrombin rapidly and transiently increased PMN adhesion by an action on the endothelial cells. The transience of the response was due to at least two factors: desensitization of the endothelial cell responsiveness to thrombin in the continued presence of the agonist; and the lability (t1/2 less than 15 min) of the effector molecules expressed by the endothelium. Experiments with exogenous platelet-activating factor (PAF) and with PAF antagonists demonstrated that PAF production, although it may facilitate the enhanced PMN adhesion seen in response to thrombin, is not sufficient to explain the reaction. By using a variety of antibodies directed against cell surface ligands, and comparing adhesion of PMN to endothelium and to protein-coated surfaces, we deduce that several endothelial ligands not previously reported as playing a role in PMN adhesion are involved in these interactions. Of particular interest was the finding that antibodies recognizing two thrombin-regulated endothelial cell surface ligands, GMP-140 and the CD63-related Ag, both inhibited adhesion of PMN to thrombin- or LPS-pretreated endothelium. We conclude that thrombin acts to enhance PMN adhesion to endothelium at least in part by transiently altering the conformation or level of expression of these ligands." @default.
- W1486844399 created "2016-06-24" @default.
- W1486844399 creator A5000170512 @default.
- W1486844399 creator A5002679402 @default.
- W1486844399 creator A5008512512 @default.
- W1486844399 creator A5024402216 @default.
- W1486844399 creator A5026191319 @default.
- W1486844399 date "1990-07-01" @default.
- W1486844399 modified "2023-10-10" @default.
- W1486844399 title "Characterization of the enhanced adhesion of neutrophil leukocytes to thrombin-stimulated endothelial cells." @default.
- W1486844399 doi "https://doi.org/10.4049/jimmunol.145.1.283" @default.
- W1486844399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1694204" @default.
- W1486844399 hasPublicationYear "1990" @default.
- W1486844399 type Work @default.
- W1486844399 sameAs 1486844399 @default.
- W1486844399 citedByCount "125" @default.
- W1486844399 countsByYear W14868443992012 @default.
- W1486844399 countsByYear W14868443992013 @default.
- W1486844399 countsByYear W14868443992014 @default.
- W1486844399 countsByYear W14868443992015 @default.
- W1486844399 countsByYear W14868443992017 @default.
- W1486844399 countsByYear W14868443992019 @default.
- W1486844399 countsByYear W14868443992020 @default.
- W1486844399 countsByYear W14868443992022 @default.
- W1486844399 crossrefType "journal-article" @default.
- W1486844399 hasAuthorship W1486844399A5000170512 @default.
- W1486844399 hasAuthorship W1486844399A5002679402 @default.
- W1486844399 hasAuthorship W1486844399A5008512512 @default.
- W1486844399 hasAuthorship W1486844399A5024402216 @default.
- W1486844399 hasAuthorship W1486844399A5026191319 @default.
- W1486844399 hasBestOaLocation W14868443991 @default.
- W1486844399 hasConcept C123012128 @default.
- W1486844399 hasConcept C132155493 @default.
- W1486844399 hasConcept C134018914 @default.
- W1486844399 hasConcept C16224149 @default.
- W1486844399 hasConcept C178790620 @default.
- W1486844399 hasConcept C183521119 @default.
- W1486844399 hasConcept C185592680 @default.
- W1486844399 hasConcept C201267052 @default.
- W1486844399 hasConcept C202751555 @default.
- W1486844399 hasConcept C203014093 @default.
- W1486844399 hasConcept C2776992346 @default.
- W1486844399 hasConcept C2777292125 @default.
- W1486844399 hasConcept C51785407 @default.
- W1486844399 hasConcept C55493867 @default.
- W1486844399 hasConcept C84416704 @default.
- W1486844399 hasConcept C85789140 @default.
- W1486844399 hasConcept C86803240 @default.
- W1486844399 hasConcept C89560881 @default.
- W1486844399 hasConcept C95444343 @default.
- W1486844399 hasConceptScore W1486844399C123012128 @default.
- W1486844399 hasConceptScore W1486844399C132155493 @default.
- W1486844399 hasConceptScore W1486844399C134018914 @default.
- W1486844399 hasConceptScore W1486844399C16224149 @default.
- W1486844399 hasConceptScore W1486844399C178790620 @default.
- W1486844399 hasConceptScore W1486844399C183521119 @default.
- W1486844399 hasConceptScore W1486844399C185592680 @default.
- W1486844399 hasConceptScore W1486844399C201267052 @default.
- W1486844399 hasConceptScore W1486844399C202751555 @default.
- W1486844399 hasConceptScore W1486844399C203014093 @default.
- W1486844399 hasConceptScore W1486844399C2776992346 @default.
- W1486844399 hasConceptScore W1486844399C2777292125 @default.
- W1486844399 hasConceptScore W1486844399C51785407 @default.
- W1486844399 hasConceptScore W1486844399C55493867 @default.
- W1486844399 hasConceptScore W1486844399C84416704 @default.
- W1486844399 hasConceptScore W1486844399C85789140 @default.
- W1486844399 hasConceptScore W1486844399C86803240 @default.
- W1486844399 hasConceptScore W1486844399C89560881 @default.
- W1486844399 hasConceptScore W1486844399C95444343 @default.
- W1486844399 hasIssue "1" @default.
- W1486844399 hasLocation W14868443991 @default.
- W1486844399 hasLocation W14868443992 @default.
- W1486844399 hasOpenAccess W1486844399 @default.
- W1486844399 hasPrimaryLocation W14868443991 @default.
- W1486844399 hasRelatedWork W146196984 @default.
- W1486844399 hasRelatedWork W1486844399 @default.
- W1486844399 hasRelatedWork W2004878050 @default.
- W1486844399 hasRelatedWork W2095828707 @default.
- W1486844399 hasRelatedWork W2095891614 @default.
- W1486844399 hasRelatedWork W2100109756 @default.
- W1486844399 hasRelatedWork W2128743891 @default.
- W1486844399 hasRelatedWork W2314376598 @default.
- W1486844399 hasRelatedWork W2317982666 @default.
- W1486844399 hasRelatedWork W2444500994 @default.
- W1486844399 hasVolume "145" @default.
- W1486844399 isParatext "false" @default.
- W1486844399 isRetracted "false" @default.
- W1486844399 magId "1486844399" @default.
- W1486844399 workType "article" @default.